Inhibitory effect of curcumin on SOS functions induced by UV irradiation

Yoshimitsu Oda

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Inhibitory effect of curcumin on SOS functions induced by UV irradiation

机译：姜黄素对紫外线辐射诱导的SOS功能的抑制作用

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The antigenoloxic effects of .curcumin, including the inhibition of SOS induction and mutagenesis by UV light, were investigated in Salmonella typhimurium TA1535/pSK1002 and Escherichia coli K-12 strains. Induction of the SOS gene (umu C) expression was assayed by measuring accumulated beta-galactosidase activity. We found that curcumin blocked umu C induction promoted by UV irradiation in a dose-dependent manner. Also, with another SOS response, Wcigle reactivation, we observed that curcumin effectively inhibited phage reactivation by UV irradiation. Furthermore, we tested the effect of curcumin on UV mutagenesis. We showed that mutagenesis induced by UV irradiation was suppressed by the addition of curcumin. Together these results indicate that curcumin acts as an inhibitor of SOS functions including UV mutagenesis.

机译：在鼠伤寒沙门氏菌TA1535 / pSK1002和大肠杆菌K-12菌株中研究了姜黄素的抗原氧作用，包括通过紫外线抑制SOS诱导和诱变。通过测量累积的β-半乳糖苷酶活性来测定SOS基因（μC）表达的诱导。我们发现姜黄素以剂量依赖的方式阻止了紫外线辐射促进的umu C诱导。此外，在另一个SOS响应Wcigle重新激活中，我们观察到姜黄素可有效抑制UV辐射对噬菌体的重新激活。此外，我们测试了姜黄素对紫外线诱变的作用。我们表明，通过添加姜黄素可以抑制由紫外线照射引起的诱变。这些结果共同表明姜黄素可作为SOS功能（包括紫外线诱变）的抑制剂。

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《Mutation Research, C. Mutation Research Letters》 |1995年第2期|共7页
作者
Yoshimitsu Oda;
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正文语种 eng
中图分类遗传学;
关键词
Curcumin; UV irradiation; umuC gene expression; Phage reactivation; Antigenotoxicity; SOS functions;

机译：姜黄素;紫外线照射;umuC基因表达;噬菌体活化;抗药性;SOS功能;

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专利

1. Inhibitory effect of curcumin on SOS functions induced by UV irradiation [J] . Yoshimitsu Oda Mutation Research, C. Mutation Research Letters . 1995,第2期

机译：姜黄素对紫外线辐射诱导的SOS功能的抑制作用
2. Radioprotective action of curcumin extracted from Curcuma longa LINN: inhibitory effect on formation of urinary 8-hydroxy-2'-deoxyguanosine, tumorigenesis, but not mortality, induced by gamma-ray irradiation. [J] . Inano H, Onoda M International Journal of Radiation Oncology, Biology, Physics . 2002,第3期

机译：姜黄提取物姜黄素的辐射防护作用：对γ-射线诱导的尿中8-羟基-2'-脱氧鸟苷的形成具有抑制作用，但对肿瘤的发生没有抑制作用。
3. Curcumin inhibits UV irradiation-induced oxidative stress and apoptotic biochemical changes in human epidermoid carcinoma A431 cells. [J] . Chan WH, Wu CC, Yu JS Journal of cellular biochemistry. . 2003,第2期

机译：姜黄素抑制人表皮样癌A431细胞中紫外线辐射诱导的氧化应激和凋亡生化变化。
4. Inhibitory effects of curcumin and capsaicin on phorbol ester-induced activation of eukaryotic transcription factors, NF-##B and AP-1 [C] . Young-Joon Surh, Seong Su Han, Young-Sam Keum, International Conference on Food Factors . 2000

机译：姜黄素和辣椒素对真核转录因子激活的抑制作用，NF - ## B和AP-1
5. Sensitivity enhancement of poly(methyl methacrylate) by radiation-induced modification and degradation of PMMA by deep UV, x-ray,e-beam and proton beam irradiations. [D] . Choi, Jin-O. 1989

机译：通过深紫外线，X射线，电子束和质子束辐照辐射诱导的PMMA改性和降解来增强聚甲基丙烯酸甲酯的敏感性。
6. Regulatory role of recF in the SOS response of Escherichia coli: impaired induction of SOS genes by UV irradiation and nalidixic acid in a recF mutant. [O] . B Thoms, W Wackernagel 1987

机译：recF在大肠杆菌的SOS反应中的调控作用：recF突变体中紫外线和萘啶酸对SOS基因的诱导作用减弱。
7. Inhibitory Effect of Dietary Curcumin on 1, 2-Dimethylhydrazine-Induced Colon Preneoplasia in Irradiated Rats [O] . 2007

机译：饮食姜黄素对1,2-二甲基肼诱导的辐照大鼠结肠癌的抑制作用

Inhibitory effect of curcumin on SOS functions induced by UV irradiation

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