PM2 DNA DAMAGE INDUCED BY 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE (MX)

Hyttinen JMT; Jansson K

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PM2 DNA DAMAGE INDUCED BY 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE (MX)

机译：3-氯-4-（二氯甲基）-5-羟基-2（5H）-呋喃酮（MX）引起的PM2 DNA损伤

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3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) is a potent direct-acting mutagen found in chlorinated drinking water. In the present study, the induction of DNA strand breaks and apurinic/apyrimidinic (AP) sites by MX in supercoiled PM2 DNA was examined using exonuclease III, which specifically cleaves the DNA at AP sites. The results showed that MX induced AP sites in great excess of direct strand breaks. In view of the known mutagenicity of AP sites, these results provide insight into the mechanism of MX-induced mutagenesis.

机译：3-氯-4-（二氯甲基）-5-羟基-2（5H）-呋喃酮（MX）是一种有效的直接作用诱变剂，存在于氯化饮用水中。在本研究中，使用外切核酸酶III检测了MX在超螺旋PM2 DNA中对DNA链断裂和嘌呤/双嘧啶（AP）位点的诱导，该酶特异性切割了AP位点上的DNA。结果表明，MX诱导的AP位点大大超过直接链断裂。鉴于已知的AP站点的诱变性，这些结果提供了对MX诱变机制的见解。

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《Mutation Research, C. Mutation Research Letters》 |1995年第4期|共4页
作者
Hyttinen JMT; Jansson K;
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正文语种 eng
中图分类遗传学;
关键词
Mx; Pm2 dna; Exonuclease iii; Apurinic/apyrimidinic site; Strand; Potent bacterial mutagen; Drinking water; Strand breaks; Acid; Assay; Cells; Sites;

机译：Mx;Pm2 dna;核酸外切酶iii;嘌呤/嘧啶核苷位点;链;强力细菌诱变剂;饮用水;链断裂;酸;测定;细胞;站点;

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1. PM2 DNA DAMAGE INDUCED BY 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE (MX) [J] . Hyttinen JMT, Jansson K Mutation Research, C. Mutation Research Letters . 1995,第4期

机译：3-氯-4-（二氯甲基）-5-羟基-2（5H）-呋喃酮（MX）引起的PM2 DNA损伤
2. Oxidative stress and DNA damage induced by a drinking-water chlorination disinfection byproduct 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in mice. [J] . Yuan J, Liu H, Zhou LH, Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 2006,第2期

机译：饮用水氯化消毒副产物3-氯-4-（二氯甲基）-5-羟基-2（5H）-呋喃酮（MX）引起的氧化应激和DNA损伤。
3. DNA damage induced by the drinking water mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in mammalian cells in vitro and in mice. [J] . Holme JA, Haddeland U, Haug K, Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 1999,第1期

机译：饮用水致突变剂3-chloro-4-（dichloromethyl）-5-hydroxy-2（5H）-呋喃酮（MX）在哺乳动物细胞中和小鼠体外诱发的DNA损伤。
4. Pilot-plant study of the formaiton of the disinfection by-product 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in dinking water [C] . C.J.Hwang, S.W.Krasner, S.A.Andrews, Ozonation for drinking water treatment . 1992

机译：在饮用水中形成消毒副产物3-氯-4-（氯甲基）-5-羟基-2（5H）-呋喃酮（MX）的中试研究
5. Removal of 3-chloro-4-dichloromethyl-5-hydroxy-2(5H)-furanone (MX) Precursors during Water Treatment Biofiltration [D] . Mian, Noreen 2018

机译：水处理生物过滤过程中去除3-氯-4-二氯甲基-5-羟基-2（5H）-呋喃酮（MX）前体
6. 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) and mutagenic activity in Massachusetts drinking water. [O] . J Michael Wright, Joel Schwartz, Terttu Vartiainen, 2002

机译：马萨诸塞州饮用水中的3-Chloro-4-（dichloromethyl）-5-hydroxy-2（5H）-呋喃酮（MX）和诱变活性。
7. Experimental studies on cellular mechanisms of the carcinogenecity of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) (Kokeellisia tutkimuksia 3-kloori-4-(dikloorimetyyli)-5-hydroksi-2(5H)-furanonin (MX) karsinogeenisuuden solutason mekanismeista) [O] . Hakulinen Pasi 100

机译：3-氯-4-（二氯甲基）-5-羟基-2（5H） - 呋喃酮（mX）致癌性的实验研究（3-氯-4-（二氯甲基）-5-羟基-2的实验研究）（5H） - 呋喃酮（mX）致癌性的细胞机制）
8. Induction of Gastrointestinal Tract Nuclear Anomalies in B6C3F1 Mice by 3-Chloro-4-(Dichloromethyl)-5-Hydroxy-2(5H)-Furanone and 3,4-(Dichloro)-5-Hydroxy-2(5H)-Furanone, Mutagenic Byproducts of Chlorine Disinfection [R] . Daniel, F. B., Olson, G. R., Stober, J. A. 1991

机译：用3-氯-4-（二氯甲基）-5-羟基-2（5H） - 呋喃酮和3,4-（二氯）-5-羟基-2（5H） - 呋喃酮诱导B6C3F1小鼠胃肠道核异常，氯消毒的诱变副产物

PM2 DNA DAMAGE INDUCED BY 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE (MX)

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