STREPTOZOTOCIN-INDUCED GENOTOXIC EFFECTS IN CHINESE HAMSTER CELLS - THE RESISTANT PHENOTYPE OF V79 CELLS

Capucci MS; Hoffmann ME; Natarajan AT

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STREPTOZOTOCIN-INDUCED GENOTOXIC EFFECTS IN CHINESE HAMSTER CELLS - THE RESISTANT PHENOTYPE OF V79 CELLS

机译：链脲佐菌素诱导的中国仓鼠细胞遗传氧化效应-V79细胞的耐药表型

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摘要

The genotoxic effects of the methylating agent streptozotocin (STZ) on Chinese hamster cells CHO-9 and V79 were evaluated. The induction of cell killing, chromosomal aberrations, sister-chromatid exchanges (SCEs) and mutations was analyzed. Comparisons were made with the the STZ aglyconic analogue N-methyl-N-nitrosourea (MNU). V79 cells were found to be more resistant than CHO-9 cells to STZ and MNU killing effects, as well as to the induction of chromosomal aberrations and SCEs; however, V79 and CHO-9 cells appeared to be equally sensitive to the induction of 6-thioguanine resistant mutants by STZ. These results suggest that an error-free mechanism that tolerates DNA methylation damage confers a resistant phenotype to V79 cells to the genotoxic effects of methylation damage.

机译：评估了甲基化剂链脲佐菌素（STZ）对中国仓鼠细胞CHO-9和V79的遗传毒性作用。分析了细胞杀伤，染色体畸变，姐妹染色单体交换（SCE）和突变的诱导。与STZ糖苷类似物N-甲基-N-亚硝基脲（MNU）进行了比较。发现V79细胞比CHO-9细胞对STZ和MNU的杀伤作用以及对染色体畸变和SCE的诱导更具抗性。然而，V79和CHO-9细胞似乎对STZ诱导的6硫代鸟嘌呤抗性突变体同样敏感。这些结果表明，耐受DNA甲基化损伤的无错机制赋予V79细胞抗性表型以甲基化损伤的基因毒性作用。

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《Mutation Research, C. Mutation Research Letters》 |1995年第2期|共7页
作者
Capucci MS; Hoffmann ME; Natarajan AT;
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正文语种 eng
中图分类遗传学;
关键词
Streptozotocin; Methylnitrosourea; Chinese hamster cells; Chromosomal; Sister chromatid exchanges; Dna; Methylnitrosourea; 6 thioguanine; Nitrosourea; Damage; Repair; Agents;

机译：链脲佐菌素;甲基亚硝基脲;中国仓鼠细胞;染色体;姐妹染色单体交换;Dna;甲基亚硝基脲;6硫代鸟嘌呤;亚硝基脲;损伤;修复;代理商;

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1. STREPTOZOTOCIN-INDUCED GENOTOXIC EFFECTS IN CHINESE HAMSTER CELLS - THE RESISTANT PHENOTYPE OF V79 CELLS [J] . Capucci MS, Hoffmann ME, Natarajan AT Mutation Research, C. Mutation Research Letters . 1995,第2期

机译：链脲佐菌素诱导的中国仓鼠细胞遗传氧化效应-V79细胞的耐药表型
2. Genotoxic effects in M5 cells and Chinese hamster V79 cells after exposure to 7Li-beam (LET=60 keV/microm) and correlation of their survival dynamics to nuclear damages and cell death. [J] . Pathak R, Dey SK, Sarma A, Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 2007,第1期

机译：暴露于7Li射线（LET = 60 keV / microm）后，M5细胞和中国仓鼠V79细胞的遗传毒性作用及其存活动态与核损伤和细胞死亡的相关性。
3. Cytotoxicity and Genotoxicity of Panel of Single- and Multiwalled Carbon Nanotubes: In Vitro Effects on Normal Syrian Hamster Embryo and Immortalized V79 Hamster Lung Cells [J] . C. Darne, F. Terzetti, C. Coulais, Journal of toxicology . 2014,第1期

机译：单壁和多壁碳纳米管面板的细胞毒性和遗传毒性：对正常叙利亚仓鼠胚胎和永生化的V79仓鼠肺细胞的体外影响
4. ELIMINATION OF THE WARBURG EFFECT IN CHINESE HAMSTER OVARY (CHO) CELLS IMPROVES CELL PHENOTYPE AS A PROTEIN PRODUCTION PLATFORM [C] . Hooman Hefzi, Ivan Martinez Monge, Nusa Pristovsek, Cell culture engineering conference . 2018

机译：消除仓鼠卵巢（CHO）细胞中的沃夫格效应可改善细胞表型作为蛋白质生产平台
5. STUDIES ON TOXIC EFFECTS OF DIETARY FATTY ACIDS ON CHINESE HAMSTER V79 CELLS [D] . Urade, Reiko 1985

机译：食用脂肪酸对中国仓鼠V79细胞毒性作用的研究
6. Cytotoxicity and Genotoxicity of Panel of Single- and Multiwalled Carbon Nanotubes: In Vitro Effects on Normal Syrian Hamster Embryo and Immortalized V79 Hamster Lung Cells [O] . C. Darne, F. Terzetti, C. Coulais, 2014

机译：单壁和多壁碳纳米管面板的细胞毒性和遗传毒性：对正常叙利亚仓鼠胚胎和永生化的V79仓鼠肺细胞的体外影响
7. V79 Chinese-hamster cells rendered resistant to high cadmium concentration also become resistant to oxidative stress. [O] . Mello-Filho, A C, Chubatsu, L S, Meneghini, R 1988

机译：抵抗高镉浓度的V79中国仓鼠细胞也变得抗氧化应激。
8. Effects of Selected Anti-Tumor-Promoting Chemicals on Metabolic Cooperationbetween Chinese Hamster V79 Cells [R] . Mills, L. J., Nelson, S. M., Malcolm, A. R. 1994

机译：选择抗肿瘤化学物质对中国仓鼠V79细胞代谢协同作用的影响

STREPTOZOTOCIN-INDUCED GENOTOXIC EFFECTS IN CHINESE HAMSTER CELLS - THE RESISTANT PHENOTYPE OF V79 CELLS

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