SALMONELLA AND MAMMALIAN-CELL MUTAGENICITY OF 3-CHLORO-4-(CHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE

Niittykoski M; Hyttinen JMT; Jansson K

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SALMONELLA AND MAMMALIAN-CELL MUTAGENICITY OF 3-CHLORO-4-(CHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE

机译：3-氯-4-（氯甲基）-5-羟基-2（5H）-呋喃酮的沙门氏菌和哺乳动物细胞突变

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摘要

3-Chloro-4-(chloromethyl)-5-hydroxy-2(5H)-furanone (CMCF), a chlorine disinfection by-product in drinking water, was mutagenic in the Salmonella/his (Ames) assay for both base-pair substitution strains (TA1535, TA100, TA102) and frameshift strains (TA97, TA98) with the highest mutagenic response observed in strain TA100 (1292 revertants/mu g). The presence in TA100 of pKM101 plasmid, which enhances error-phone DNA repair, greatly increased susceptibility to CMCF mutagenicity relative to the isogenic strain TA1535 lacking pKM101. In the Chinese hamster ovary (CHO) cell hprt (6-thioguanine resistance) locus assay, the mutagenicity of CMCF (1.04 mutants/10(6) clonable cells per mu g/ml) was barely detectable because of the low mutagenicity/cytotoxicity ratio. From the present experiments it appears that CMCF acts in a manner similar to that of another drinking water mutagen, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX). However, CMFC appears to be a less potent mutagen in vitro than MX.

机译：饮用水中的氯消毒副产物3-Chloro-4-（chloromethyl）-5-hydroxy-2（5H）-呋喃酮（CMCF）在沙门氏菌/他的（Ames）分析中对两个碱基对均具有诱变性在TA100菌株中观察到的诱变响应最高的替代菌株（TA1535，TA100，TA102）和移码菌株（TA97，TA98）（1292个回复株/μg）。与缺乏pKM101的同基因菌株TA1535相比，pKM101质粒在TA100中的存在可增强错误电话DNA修复，大大提高了对CMCF致突变性的敏感性。在中国仓鼠卵巢（CHO）细胞hprt（6-硫鸟嘌呤抗性）基因座测定中，由于低致突变性/细胞毒性比，几乎无法检测到CMCF的致突变性（每亩g / ml 1.04个突变体/ 10（6）可克隆细胞）。。从目前的实验看来，CMCF以类似于另一种饮用水诱变剂3-氯-4-（二氯甲基）-5-羟基-2（5H）-呋喃酮（MX）的方式起作用。但是，CMFC的体外诱变作用似乎不如MX。

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来源
《Mutation Research, C. Mutation Research Letters》 |1995年第1期|共5页
作者
Niittykoski M; Hyttinen JMT; Jansson K;
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正文语种 eng
中图分类遗传学;
关键词
Chlorohydroxyfuranone; Drinking water; Mutagenicity test; Potent bacterial mutagen; Drinking water; 3 chloro 4 (dichloromethyl) 5 hydroxy 2(5h) furanone; Acid;

机译：氯羟基呋喃酮;饮用水;致突变性测试;强力细菌诱变剂;饮用水;3氯4（二氯甲基）5羟基2（5h）呋喃酮;酸;

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1. SALMONELLA AND MAMMALIAN-CELL MUTAGENICITY OF 3-CHLORO-4-(CHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE [J] . Niittykoski M, Hyttinen JMT, Jansson K Mutation Research, C. Mutation Research Letters . 1995,第1期

机译：3-氯-4-（氯甲基）-5-羟基-2（5H）-呋喃酮的沙门氏菌和哺乳动物细胞突变
2. Identification of Adducts Formed in the Reaction of the Bacterial Mutagen 3-Chloro-4-(chloromethyl)-5-hydroxy-2(5H)-furanone with Cytidine [J] . D.Pluskota-Karwatka, T.Munter, F.Le Curieux Polish Journal of Chemistry . 2007,第5a6期

机译：细菌诱变剂3-Chloro-4-（chloromethyl）-5-hydroxy-2（5H）-呋喃酮与胞苷反应中形成的加合物的鉴定
3. Identification of adducts formed in reactions of 2-deoxyadenosine and calf thymus DNA with the bacterial mutagen 3-chloro-4-(chloromethyl)-5-hydroxy-2(5H)-furanone. [J] . Munter T, Le Curieux-F, Sjoholm R, Chemical research in toxicology . 1999,第12期

机译：鉴定2-脱氧腺苷和小牛胸腺DNA与细菌诱变剂3-氯-4-（氯甲基）-5-羟基-2（5H）-呋喃酮形成的加合物。
4. Pilot-plant study of the formaiton of the disinfection by-product 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in dinking water [C] . C.J.Hwang, S.W.Krasner, S.A.Andrews, Ozonation for drinking water treatment . 1992

机译：在饮用水中形成消毒副产物3-氯-4-（氯甲基）-5-羟基-2（5H）-呋喃酮（MX）的中试研究
5. Removal of 3-chloro-4-dichloromethyl-5-hydroxy-2(5H)-furanone (MX) Precursors during Water Treatment Biofiltration [D] . Mian, Noreen 2018

机译：水处理生物过滤过程中去除3-氯-4-二氯甲基-5-羟基-2（5H）-呋喃酮（MX）前体
6. 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) and mutagenic activity in Massachusetts drinking water. [O] . J Michael Wright, Joel Schwartz, Terttu Vartiainen, 2002

机译：马萨诸塞州饮用水中的3-Chloro-4-（dichloromethyl）-5-hydroxy-2（5H）-呋喃酮（MX）和诱变活性。
7. 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) and mutagenic activity in Massachusetts drinking water. [O] . Wright J Michael, Schwartz Joel, Vartiainen Terttu, 100

机译：马萨诸塞州饮用水中的3-Chloro-4-（dichloromethyl）-5-hydroxy-2（5H）-呋喃酮（MX）和诱变活性。
8. Induction of Gastrointestinal Tract Nuclear Anomalies in B6C3F1 Mice by 3-Chloro-4-(Dichloromethyl)-5-Hydroxy-2(5H)-Furanone and 3,4-(Dichloro)-5-Hydroxy-2(5H)-Furanone, Mutagenic Byproducts of Chlorine Disinfection [R] . Daniel, F. B., Olson, G. R., Stober, J. A. 1991

机译：用3-氯-4-（二氯甲基）-5-羟基-2（5H） - 呋喃酮和3,4-（二氯）-5-羟基-2（5H） - 呋喃酮诱导B6C3F1小鼠胃肠道核异常，氯消毒的诱变副产物

SALMONELLA AND MAMMALIAN-CELL MUTAGENICITY OF 3-CHLORO-4-(CHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE

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