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首页> 外文期刊>Mutation Research, C. Mutation Research Letters >ENHANCED CYTO- AND GENOTOXICITY OF TETRACYCLINE IN WILSON DISEASE FIBROBLASTS
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ENHANCED CYTO- AND GENOTOXICITY OF TETRACYCLINE IN WILSON DISEASE FIBROBLASTS

机译：威尔森病成纤维细胞中四环素的细胞毒性和遗传毒性

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摘要

Tetracyline (TC) exerts DNA damaging properties which are accelerated in the presence of copper(II). Thereby, reactive oxygen species are generated. We investigated, if copper-accumulating cells show a higher sensitivity to TC compared to normal cells. Fibroblasts with an increased copper content were derived from patients of two genetic disorders, Wilson disease (WD) and Menkes disease (MD). Cytotoxic and genotoxic effects of TC were investigated in different human fibroblasts. The inhibition of cell growth by TC was measured in two normal fibroblast lines, fibroblast lines of two patients with WD and one patient with MD. While TC inhibited cell growth at similar concentrations in normal fibroblasts and the MD fibroblasts, the WD cells were much more sensitive. Furthermore, an increased inhibition of DNA synthesis and an enhanced induction of unscheduled DNA synthesis (UDS) was found in WD cells after a TC-treatment compared to normal cells.
机译：Tetracyline（TC）具有DNA破坏特性，在铜（II）的存在下会加速降解。由此，产生活性氧。我们调查了铜富集细胞对TC的敏感性是否比正常细胞高。铜含量增加的成纤维细胞来自两种遗传性疾病，威尔逊病（WD）和门克斯病（MD）。在不同的人类成纤维细胞中研究了TC的细胞毒性和遗传毒性作用。在两个正常成纤维细胞系中测量了TC对细胞生长的抑制作用，其中两个患有WD的患者和一个患有MD的患者的成纤维细胞。 TC在正常成纤维细胞和MD成纤维细胞中以相似的浓度抑制细胞生长时，WD细胞更为敏感。此外，与正常细胞相比，在TC处理后的WD细胞中发现对DNA合成的抑制作用增强，对非计划DNA合成（UDS）的诱导作用增强。

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