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首页> 外文期刊>Mutation Research, C. Mutation Research Letters >VITAMIN E PREVENTS EXERCISE-INDUCED DNA DAMAGE
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VITAMIN E PREVENTS EXERCISE-INDUCED DNA DAMAGE

机译：维生素E防止运动引起的DNA损伤

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摘要

The single cell gel test (SCG test or comet assay) was used to study DNA damage in peripheral white blood cells (WBC) of humans after a single bout of exhaustive exercise and the effect of vitamin supplementation. Human subjects were asked to run on a treadmill until exhaustion and blood samples were taken before and 24 h after the run. A clear increase in DNA strand breakage was observed in the 24-h sample of all probands. A short-term application of multivitamin pills or vitamin E (3 x 800 mg) resulted in a significantly smaller increase of DNA effects in WBC of some probands, When the volunteers were given a supplement of vitamin E (1200 mg daily) for 14 days prior to a run, exercise-induced DNA damage was clearly reduced in all probands. In four out of five subjects, vitamin supplementation completely prevented the induction of DNA damage after exhaustive exercise. Intake of vitamin E for 14 days led to a clear increase in vitamin E serum concentrations. Malondialdehyde (MDA), a marker of lipid peroxidation, was measured in the serum of probands in tests with and without vitamin supplementation for 14 days. MDA concentrations were significantly decreased following vitamin E supplementation but not significantly changed 15 min and 24 h after a run. Our results demonstrate that vitamin E prevents exercise-induced DNA damage and indicate that DNA breakage occurs in WBC after exhaustive exercise as a consequence of oxidative stress.
机译：单细胞凝胶测试（SCG测试或彗星分析）用于研究单次力竭运动和补充维生素的作用后人外周血白细胞（WBC）的DNA损伤。要求人类受试者在跑步机上跑步，直到跑步前和跑步后24小时都筋疲力尽。在所有先证者的24小时样本中观察到DNA链断裂的明显增加。短期应用多种维生素药丸或维生素E（3 x 800毫克）会使某些先证者的白细胞中DNA的作用显着降低，当为志愿者提供14天的维生素E补充剂（每天1200 mg）时跑步前，所有先证者运动引起的DNA损伤均明显减少。在五分之四的受试者中，补充维生素完全可以防止力竭运动后诱发DNA损伤。摄入维生素E 14天导致维生素E血清浓度明显增加。在添加和不添加维生素14天的测试中，先证者血清中均测定了脂质过氧化的标志物丙二醛（MDA）。补充维生素E后，MDA浓度显着降低，但跑步后15分钟和24小时没有明显改变。我们的结果表明，维生素E可以防止运动引起的DNA损伤，并表明由于氧化应激，力竭运动后WBC中会发生DNA断裂。

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