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首页> 外文期刊>Mutation Research, C. Mutation Research Letters >HERITABLE TRANSLOCATIONS INDUCED BY INHALATION EXPOSURE OF MALE MICE TO 1,3-BUTADIENE
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HERITABLE TRANSLOCATIONS INDUCED BY INHALATION EXPOSURE OF MALE MICE TO 1,3-BUTADIENE

机译：吸入小鼠暴露于1,3-丁二烯引起的易位转移

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摘要

Previously, we reported that dominant lethal mutations were induced in spermatids after inhalation exposure of male (102/El X C3H/El)F-1 mice to 1300 ppm of 1,3-butadiene on 5 days for 6 h per day (exposure dose 39 000 ppm h). The same inhalation exposure was given to male C3H/El inbred mice which were mated to inbred line 102/El females 8-14 d after the end of exposure. Male and female F-1 hybrid progeny were tested for the presence of heritable translocations by observation of litter sizes and by cytogenetic analyses in meiotic and somatic cells. 1,3-Butadiene induced heritable translocations in late spermatids. The translocation frequency after 1,3-butadiene exposure to 39 000 ppm h was 2.7% (16 translocation heterozygotes among 599 F-1 offspring). This frequency is 54 times higher than the historical control frequency (0.05%; 5 translocation heterozygotes among 9500 F-1 offsping). Thus, 1,3-butadiene causes heritable germ cell effects in mice.
机译：先前，我们报道了雄性（102 / El X C3H / El）F-1小鼠在5天每天6小时（暴露剂量）中吸入1300 ppm 1,3-丁二烯的吸入后，在精子细胞中诱导了显性致死突变。 39 000 ppm h）。对雄性C3H / E1近交小鼠给予相同的吸入暴露，其在暴露结束后8-14天与近交系102 / E1雌性交配。通过观察产仔数并通过减数分裂和体细胞的细胞遗传学分析，测试了雄性和雌性F-1杂种后代是否存在遗传易位。 1,3-丁二烯诱导晚期精子的遗传易位。 1,3-丁二烯暴露于39000 ppm h后的易位频率为2.7％（599 F-1后代中16个易位杂合子）。该频率比历史控制频率高54倍（0.05％; 9500 F-1引爆中有5个易位杂合子）。因此，1,3-丁二烯在小鼠中引起遗传性生殖细胞效应。

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