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首页> 外文期刊>Mutation Research, C. Mutation Research Letters >BASELINE AND MITOMYCIN C (MMC)-INDUCED SISTER-CHROMATID EXCHANGES IN XX AND XY CELLS OF CALLITHRIX JACCHUS CHIMERIC TWINS
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BASELINE AND MITOMYCIN C (MMC)-INDUCED SISTER-CHROMATID EXCHANGES IN XX AND XY CELLS OF CALLITHRIX JACCHUS CHIMERIC TWINS

机译：基线和由丝裂霉素C（MMC）诱导的Callithrix Jacchus嵌合双胞胎XX和XY细胞中的酯-染色体交换

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摘要

Lymphocytes from chimeric individuals of the species Callithrix jacchus (Primates) were examined to evaluate differences in the frequency of sister chromatid exchanges (SCE) between XX and XY cells. The aim was to discover whether SCE differ according to genetic sex and whether XX and XY cells show a different sensitivity to SCE inducing agents. This experimental model has enabled us to eliminate the possible differences caused by environmental factors. The results obtained do not reveal significant differences between male and female cells, in either the baseline SCE frequency or that induced by mitomycin C at concentrations of 0.01 and 0.03 mu g/ml. No significant differences were observed in the distribution of high SCE frequency cells (HFC), even if it is possible to observe a higher level of exchanges in XX cells in each trial. With regard to the phenotypic sex, there appears to be a trend towards slightly higher SCE rates in females, even if results are not statistically significant.
机译：检查了来自Callithrix jacchus（Primates）物种的嵌合个体的淋巴细胞，以评估XX和XY细胞之间姐妹染色单体交换（SCE）频率的差异。目的是发现SCE是否因遗传性别而异，以及XX和XY细胞对SCE诱导剂的敏感性是否不同。这个实验模型使我们能够消除由环境因素引起的可能差异。所获得的结果在基线SCE频率或丝裂霉素C诱导的0.01和0.03μg / ml浓度下，均未显示雄性和雌性细胞之间的显着差异。即使可以在每个试验中在XX个细胞中观察到更高水平的交换，在高SCE频率细胞（HFC）的分布中也没有观察到显着差异。关于表型性别，即使结果在统计学上不显着，女性的SCE似乎也有趋势。

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