EFFECT OF RED CELLS AND PLASMA BLOOD IN DETERMINING INDIVIDUAL LYMPHOCYTES SENSITIVITY TO DIEPOXYBUTANE ASSESSED BY IN VITRO INDUCED SISTER CHROMATID EXCHANGES

Landi S; Ponzanelli I; Barale R

首页> 外文期刊>Mutation Research, C. Mutation Research Letters >EFFECT OF RED CELLS AND PLASMA BLOOD IN DETERMINING INDIVIDUAL LYMPHOCYTES SENSITIVITY TO DIEPOXYBUTANE ASSESSED BY IN VITRO INDUCED SISTER CHROMATID EXCHANGES

【24h】

EFFECT OF RED CELLS AND PLASMA BLOOD IN DETERMINING INDIVIDUAL LYMPHOCYTES SENSITIVITY TO DIEPOXYBUTANE ASSESSED BY IN VITRO INDUCED SISTER CHROMATID EXCHANGES

机译：红细胞和血浆血液对体外诱导的姐妹染色体交换评估个体淋巴细胞对双氧丁烷敏感性的影响

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Previous authors investigated individual responsiveness to mutagens by assessing cytogenetic damage following in vitro treatment. Diepoxybutane (DEB) has been used to assess chromosome instability both in repair-deficient and normal subjects. Since bimodal distribution of sister chromatid exchanges (SCEs) or chromosomal aberration (CAs) frequencies has been observed in normal subjects, we investigated the possible factors determining the 'high-respondent' phenotype. The bimodal-shaped distribution suggested the presence of a single factor responsible far this phenotype. Our data showed that red blood cells are involved in determining the sensitivity of lymphocytes to DEB induced SCE. The existence of a polymorphic factor in red cells involved in DEB detoxification is suggested.

机译：先前的作者通过评估体外治疗后的细胞遗传学损伤，研究了个体对诱变剂的反应性。二环氧丁烷（DEB）已用于评估修复缺陷和正常受试者的染色体不稳定性。由于已在正常受试者中观察到姐妹染色单体交换（SCE）或染色体畸变（CAs）频率的双峰分布，因此我们研究了确定“高响应”表型的可能因素。双峰状分布表明，存在一个单独的因素负责该表型。我们的数据表明，红细胞参与确定淋巴细胞对DEB诱导的SCE的敏感性。提示参与DEB排毒的红细胞中存在多态性因子。

著录项

来源
《Mutation Research, C. Mutation Research Letters》 |1995年第3期|共7页
作者
Landi S; Ponzanelli I; Barale R;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类遗传学;
关键词
Sister chromatid exchange; Erythrocyte; Red cell; Individual; Chromosome instability syndromes; Cultured human lymphocytes; Ataxia telangiectasia; Fanconi anemia; Bimodal distribution; Sce; induction; Erythrocytes; Aberrations; Glutathione; Frequency;

机译：姐妹染色单体交换;红细胞;红细胞;个体;染色体不稳定综合征;培养的人淋巴细胞;共济失调毛细血管扩张症;范可尼贫血;双峰分布;Sce;诱导;红细胞;畸变;谷胱甘肽;频率;

相似文献

外文文献
中文文献
专利

1. EFFECT OF RED CELLS AND PLASMA BLOOD IN DETERMINING INDIVIDUAL LYMPHOCYTES SENSITIVITY TO DIEPOXYBUTANE ASSESSED BY IN VITRO INDUCED SISTER CHROMATID EXCHANGES [J] . Landi S, Ponzanelli I, Barale R Mutation Research, C. Mutation Research Letters . 1995,第3期

机译：红细胞和血浆血液对体外诱导的姐妹染色体交换评估个体淋巴细胞对双氧丁烷敏感性的影响
2. Chromosomal aberrations, sister chromatid exchanges and micronuclei induced by pentoxifylline in in vitro cultivated Chinese hamster cells (V79) and human blood lymphocytes. [J] . Bozsakyova E, Chalupa I, Sebova L, Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 2001,第1a2期

机译：己酮可可碱在体外培养的中国仓鼠细胞（V79）和人血淋巴细胞中引起的染色体畸变，姐妹染色单体交换和微核。
3. Influence of duration of exposure to styrene oxide on sister chromatid exchanges and cell-cycle kinetics in cultured human blood lymphocytes in vitro. [J] . Chakrabarti S, Zhang XX, Richer CL Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 1997,第1期

机译：暴露于苯乙烯氧化物的持续时间对体外培养的人血淋巴细胞中姐妹染色单体交换和细胞周期动力学的影响。
4. EFFECTS OF CARVACROL ON SISTER CHROMATID EXCHANGES IN HUMAN LYMPHOCYTE CULTURES [C] . EVRIM IPEK, BERRIN AYAZ TUYLU, HULYA ZEYTIMOGLU Annual Meeting of the Japanese Association for Animal Cell Technology . 2003

机译：Carvacrol对人淋巴细胞培养症症患者染色体交换的影响
5. FREQUENCY OF SISTER CHROMATID EXCHANGES AND CELL CYCLE KINETICS IN CULTURED HUMAN LYMPHOCYTES TREATED WITH SELENIUM ALONE OR SELENIUM AND METHYLNITROSOUREA. [D] . KHALIL, AHMAD MOHAMMAD. 1987

机译：硒单独或硒和亚甲基亚硝基脲处理的人淋巴细胞中的染色体染色交换和细胞周期动力学的频率。
6. Sensitivity of lymphocytes from vulcanizers to the in vitro induction of sister chromatid exchanges. [O] . F Degrassi, R De Salvia, M Fiore, 1993

机译：硫化剂产生的淋巴细胞对姐妹染色单体交换体外诱导的敏感性。
7. Influence of erythrocyte glutathione S-transferase T1 on sister chromatid exchanges induced by diepoxybutane in cultured human lymphocytes [O] . Katarina Pelin, Ari Hirvonen, Hannu Norppa 1996

机译：红细胞谷胱甘肽S-转移酶T1对培养人淋巴细胞中浸渍氧丁烷诱导的筛选染色交换的影响

EFFECT OF RED CELLS AND PLASMA BLOOD IN DETERMINING INDIVIDUAL LYMPHOCYTES SENSITIVITY TO DIEPOXYBUTANE ASSESSED BY IN VITRO INDUCED SISTER CHROMATID EXCHANGES

摘要

著录项

相似文献

相关主题

期刊订阅