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首页> 外文期刊>Mutation Research, C. Mutation Research Letters >EFFECT OF PREINDUCTION OF METALLOTHIONEIN SYNTHESIS ON CLASTOGENICITY OF ANTICANCER DRUGS IN MICE
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EFFECT OF PREINDUCTION OF METALLOTHIONEIN SYNTHESIS ON CLASTOGENICITY OF ANTICANCER DRUGS IN MICE

机译：预诱导金属硫蛋白合成对小鼠抗癌药的致塑性的影响

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摘要

The effect of pretreatment with metallothionein (MT) inducers (bismuth nitrate or zinc chloride) on clastogenicity of anticancer drugs was investigated. Bismuth nitrate (50 mu mol/kg) or zinc chloride (400 mu mol/kg) was administered s.c. to mice once a day for two days prior to treatment with 3.3 mu mol/kg of cis-diamminedichloroplatinum(II) (cis-DDP), 3.4 mu mol/kg of adriamycin (ADR), 72 mu mol/kg of cyclophosphamide (CPA) or 0.41 mu mol/kg of L-phenylalanine mustard (L-PAM). The frequency of occurrence of erythrocytes with micronuclei in bone marrow was increased by each anticancer drug at 24 h after treatment. Micronucleus formation was significantly prevented by pretreatment with either bismuth nitrate or zinc chloride. MT concentration in bone marrow cells of mice at the time of treatment with anticancer drugs increased to 2- and 3.5-fold by pretreatment with bismuth nitrate and zinc chloride, respectively. These results indicate that MT induction in bone marrow cells effectively prevents micronucleus induction of anticancer drugs.
机译：研究了金属硫蛋白（MT）诱导剂（硝酸铋或氯化锌）预处理对抗癌药的致乳性的影响。皮下注射硝酸铋（50μmol/ kg）或氯化锌（400μmol/ kg）。每天两次，每天两次，每天用3.3μmol / kg的顺二氨二氯铂（II）（cis-DDP），3.4μmol / kg的阿霉素（ADR），72μmol / kg的环磷酰胺（CPA）处理）或0.41μmol / kg的L-苯丙氨酸芥末（L-PAM）。在治疗后24小时，每种抗癌药物都会增加骨髓中具有微核的红细胞的出现频率。用硝酸铋或氯化锌预处理可显着防止微核形成。通过用硝酸铋和氯化锌预处理，在用抗癌药治疗时，小鼠骨髓细胞中的MT浓度分别增加了2倍和3.5倍。这些结果表明，骨髓细胞中MT的诱导有效地阻止了抗癌药物的微核诱导。

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