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首页> 外文期刊>Mutation Research, E. Environmental Mutagenesis and Related Subjects >Evaluation of micronuclei in exfoliated urothelial cells and urinary thioether excretion of smokers
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Evaluation of micronuclei in exfoliated urothelial cells and urinary thioether excretion of smokers

机译：吸烟者脱落的尿路上皮细胞微核的评估和尿硫醚的排泄

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摘要

Mutagens are present in large quantities in the urine of cigarette smokers, thus, their urothelial cells may represent a possible target for absorbed and excreted mutagens. Our aim is to validate the micronucleus (MN) test in exfoliated urothelial cells obtained from urine samples of cigarette smokers. The urinary thioether (UT) test is also carried out on the same individuals in order to find out whether there is any correlation between these two end-points. The mean ( +- SE) MN frequency and UT determination is 1.93 (±0.11)% and 9.71 (±1.61) mmol SH/mol creatinine for 23 smokers, and 0.66 (±0.05)% and 4.20 (±0.56) mmol SH/mol creatinine for 20 nonsmokers. Our results show a higher frequency of micronucleated ceils (p < 0.001) and higher excretion of UTs (p < 0.05) in smokers as compared to nonsmokers. Concentrations of UTs and MN frequencies increased with tobacco consumption. The MN frequencies showed only a marginal increase, not significant (p > 0.05), after passive smoking compared to nonsmoking values. There was no significant correlation between MN frequencies and UTs. either in smokers (r = -0.164, p > 0.05) or in nonsmokers (r = -0.018, p > 0.05). Our data demonstrate tobacco-induced chromosome damage in bladder tissue consistent with increased risk of cancer at this site among smokers.
机译：吸烟者尿液中大量存在突变基因，因此，其尿路上皮细胞可能代表了诱变剂被吸收和排泄的可能目标。我们的目的是验证从吸烟者尿液样本中获得的脱落的尿路上皮细胞中的微核（MN）测试。尿硫醚（UT）测试也对同一个体进行，以查明这两个端点之间是否存在任何相关性。 23名吸烟者的平均（±SE）MN频率和UT测定分别为1.93（±0.11）％和9.71（±1.61）mmol SH / mol肌酐，以及0.66（±0.05）％和4.20（±0.56）mmol SH / mol mol肌酐可治疗20名不吸烟者。我们的研究结果显示，与不吸烟者相比，吸烟者中微核细胞的发生率更高（p <0.001），UTs排泄率更高（p <0.05）。 UT和MN的浓度随烟草消费量的增加而增加。与非吸烟值相比，被动吸烟后MN频率仅显示出少量增加，无显着性（p> 0.05）。 MN频率和UT之间没有显着相关性。吸烟者（r = -0.164，p> 0.05）或非吸烟者（r = -0.018，p> 0.05）。我们的数据表明，烟草诱导的膀胱组织染色体损伤与吸烟者此部位患癌风险的增加一致。

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