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首页> 外文期刊>Mutation Research, E. Environmental Mutagenesis and Related Subjects >ANTIMUTAGENICITY OF AN ACETONE EXTRACT OF YOGURT
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ANTIMUTAGENICITY OF AN ACETONE EXTRACT OF YOGURT

机译：酸奶丙酮提取物的防腐性

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摘要

Reconstituted non-fat dry milk powder, fermented by a mixture of Streptococcus thermophilus CH3 and Lactobacillus bulgaricus 191R to produce yogurt, was freeze-dried and extracted in acetone. After evaporation of the acetone, the extract was dissolved in dimethyl sulfoxide (DMSO) and tested for antimutagenicity. In the Ames test, significant dose-dependent activity was observed against N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), 4-nitroquinoline-N-oxide (4NQO), 3,2'-dimethyl-4-aminobiphenyl (DMAB), 9,10-dimethyl-1,2-benz[a]anthracene (DMBA), and 3-amino-1-methyl-5H-pyrido[4,3-b]indole acetate (Trp-P-2). Weak activity was observed against 1,2,7,8-di-epoxyoctane (DEO), and no activity was observed against methyl methanesulfonate (MMS), ethyl methanesulfonate (EMS), or aflatoxin B1 (AFB1). In a related assay (Saccharomyces cerevisiae D7), significant antimutagenic activity was detected against MNNG and 4NQO.
机译：将重组的脱脂奶粉（通过嗜热链球菌CH3和保加利亚乳杆菌191R的混合物发酵）制成酸奶，然后冷冻干燥并在丙酮中提取。蒸发丙酮后，将提取物溶于二甲基亚砜（DMSO）中，并测试其抗诱变性。在Ames测试中，观察到针对N-甲基-N'-硝基-N-亚硝基胍（MNNG），4-硝基喹啉-N-氧化物（4NQO），3,2'-二甲基-4-氨基联苯的显着剂量依赖性活性（DMAB），9,10-二甲基-1,2-苯并[a]蒽（DMBA）和3-氨基-1-甲基-5H-吡啶并[4,3-b]乙酸吲哚酯（Trp-P-2 ）。观察到对1,2,7,8-二环氧辛烷（DEO）的活性较弱，而对甲磺酸甲酯（MMS），甲磺酸乙酯（EMS）或黄曲霉毒素B1（AFB1）没有活性。在相关的测定中（酿酒酵母D7），发现了针对MNNG和4NQO的显着抗突变活性。

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