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首页> 外文期刊>Mutation research. Genetic toxicology testing >COMPARATIVE MUTAGENICITY TESTING OF CEFTIOFUR SODIUM .2. CYTOGENETIC DAMAGE INDUCED IN VITRO BY CEFTIOFUR IS REVERSIBLE AND IS DUE TO CELL CYCLE DELAY
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COMPARATIVE MUTAGENICITY TESTING OF CEFTIOFUR SODIUM .2. CYTOGENETIC DAMAGE INDUCED IN VITRO BY CEFTIOFUR IS REVERSIBLE AND IS DUE TO CELL CYCLE DELAY

机译：头孢呋喃钠的致突变性对比测试.2。头孢噻呋体外诱导的细胞遗传学损伤是可逆的，并且是由于细胞周期延迟引起的

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摘要

Ceftiofur, a new generation of cephalosporin antibiotic, used to combat bacterial respiratory disease in growing cattle and swine, has been tested in a battery of genetic toxicology assays (Aaron et al., 1995a) and been shown to produce chromosome aberrations in CHO cells following treatment for 44 h. No evidence of aberration induction was seen at shorter, i.e., 20 h, treatment time nor was any suggestion of clastogenicity seen in the presence of S9 metabolic activation. The experiments reported here were undertaken to determine significance of this observation and elucidate the reason for clastogenesis in the earlier experiments. Briefly, ceftiofur was found to not affect the pH or osmolality of the treatment solutions nor were enzymes generally associated with cell death released during the treatment period. The aberrations were found to be reversible, and thus, doubt was cast concerning the potential for direct DNA damage as a causative factor. The most profound effect of ceftiofur treatment at this level was the dramatic effect on cell cycle kinetics and therefore the clastogenic effects observed following exposure to ceftiofur in vitro appear to be due to prolongation of the cell cycle.
机译：头孢噻呋，一种用于对抗生长中的牛和猪的细菌性呼吸道疾病的新一代头孢菌素抗生素，已在一系列遗传毒理学检测中进行了测试（Aaron等人，1995a），并被证明可在CHO细胞中产生染色体畸变处理44小时。在更短的时间，即20小时，没有观察到畸变诱导的证据，在存在S9代谢活化的情况下也没有发现任何致裂性的迹象。进行此处报道的实验是为了确定该观察结果的重要性，并在较早的实验中阐明产生裂痕的原因。简而言之，发现头孢噻呋不影响处理溶液的pH或重量克分子渗透压浓度，也不影响在治疗期间释放的通常与细胞死亡有关的酶。发现这些像差是可逆的，因此，人们怀疑直接DNA损伤是可能的致病因素。在此水平上头孢噻呋治疗的最深刻影响是对细胞周期动力学的显着影响，因此在体外暴露于头孢噻呋后观察到的致胶结作用似乎是由于细胞周期延长所致。

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