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首页> 外文期刊>Mutation Research. Reviews in Mutation Research >Evaluation of chromosome aberration and micronucleus frequencie in blood lymphocytes of workers exposed to low concentrations of benzene
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Evaluation of chromosome aberration and micronucleus frequencie in blood lymphocytes of workers exposed to low concentrations of benzene

机译：低浓度苯暴露工人血液淋巴细胞染色体畸变和微核频率的评估

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The frequency of chromosome aberrations (CA) and micronuclei (MN) was investigated in the peripheral lymphocytes of workers occupationally exposed to low or very low concentrations of benzene. The study included 43 exposed workers (all males), namely 19 fuel-tanker drivers and 24 filling-station attendants, and 31 male subjects with no occupational exposure to the toxicant (controls). Benzene exposure was verified by means of environmental monitoring with passive personal samplers (Radiello?), and through biological monitoring, i.e. by measurement of urinary trans.trans-muconic acid, S-phenylmercapturic acid and benzene. The frequency of CA and MN in peripheral lymphocytes was determined according to standard procedures. Exposure to benzene was found to be significantly higher for fuel-tanker drivers (median 246.6 (xg/m3) than for filling-station attendants (median 19.9 mug/m3). Both groups had significantly higher exposure than controls (median 4.3 ,ug/m3). No increased frequency of CA and MN was observed in either fuel-tanker drivers or filling-station attendants compared with controls. In all subjects examined as a single group, the frequency of MN was significantly dependent on age. Only in the fuel-tanker drivers was the frequency of MN found to depend not only on age, but also on exposure to benzene. In conclusion, the frequency of MN, but not of CA, could be influenced by exposure to benzene concentrations of up to one order of magnitude lower than the threshold limit value (time-weighted average).
机译：在暴露于低浓度或极低浓度苯的工人的外周淋巴细胞中研究了染色体畸变（CA）和微核（MN）的频率。该研究包括43名暴露工人（全部为男性），即19名加油站驾驶员和24名加油站服务员，以及31名无职业暴露于毒物的男性受试者（对照）。通过使用被动式个人采样器（Radiello？）进行环境监测，以及通过生物监测，即通过测量尿中反式-反-粘康酸，S-苯硫醇酸和苯来验证苯的暴露。根据标准程序确定外周淋巴细胞中CA和MN的频率。燃油加油司机的苯暴露水平（中位数为246.6（xg / m3））显着高于加油站乘务员（中位数为19.9杯/立方米），两组均显着高于对照组（中位数为4.3μg/ m3）。 m3）。与对照组相比，油轮驾驶员或加油站服务员的CA和MN频率均未升高，在所有受试者中，MN的频率均显着取决于年龄。 -油轮驱动因素是发现MN的频率不仅取决于年龄，还取决于其与苯的接触量，总之，MN的频率（而不是CA的影响量）可能受到暴露于浓度高达一个数量级的苯的影响。幅度低于阈值限值（时间加权平均值）。

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