Reflections on the development and application of FISH whole chromosome painting

Tucker James D.

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Reflections on the development and application of FISH whole chromosome painting

机译：对FISH全染色体绘画发展与应用的思考。

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This review describes my personal reflections on the development of whole chromosome painting using fluorescence in situ hybridization and how my laboratory applied the technology in humans and in animal models. The trials and triumphs of the early years are emphasized, along with some of the scientific surprises that were encountered along the way. Scientific issues that my laboratory addressed using chromosome painting technologies are summarized and related to questions in radiation dosimetry, chemical clastogenesis, translocation persistence, and translocation frequencies in unexposed people. A description is provided of scientific controversies that were encountered and how they were resolved. I hope this paper will encourage young scientists to follow their passions and pursue their scientific dreams even if the task seems daunting and the circumstances appear exceedingly difficult. In my case the journey has been challenging, exciting, and richly rewarding on many levels. (C) 2014 Elsevier B.V. All rights reserved.

机译：这篇评论描述了我对使用荧光原位杂交技术绘制整个染色体画的个人看法，以及我的实验室如何将该技术应用于人类和动物模型。强调了早期的尝试和胜利，以及沿途遇到的一些科学惊喜。总结了我的实验室使用染色体绘画技术解决的科学问题，这些问题与辐射剂量法，化学成裂作用，易位持久性和未暴露人群易位频率有关。提供了所遇到的科学争议及其解决方式的描述。我希望本文能够鼓励年轻的科学家追随自己的激情，追求自己的科学梦想，即使这项任务看起来艰巨并且情况似乎极其困难。就我而言，这个旅程在许多层面上都是充满挑战，令人兴奋和收获丰厚的。（C）2014 Elsevier B.V.保留所有权利。

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《Mutation Research. Reviews in Mutation Research》 |2015年第null期|共13页
作者
Tucker James D.;
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正文语种 eng
中图分类变异;
关键词
Chromosome painting; Fluorescence in situ hybridization; Molecular cytogenetics; Human cytogenetics; Rodent cytogenetics; Historical review;

机译：染色体绘画;荧光原位杂交;分子细胞遗传学;人类细胞遗传学;啮齿动物细胞遗传学;历史回顾;
入库时间 2022-08-18 12:02:10

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1. Reflections on the development and application of FISH whole chromosome painting [J] . Tucker James D. Mutation Research. Reviews in Mutation Research . 2015,第Null期

机译：对FISH全染色体绘画发展与应用的思考。
2. Development of a sequential multicolor-FISH approach with 13 chromosome-specific painting probes for the rapid identification of river buffalo (Bubalus bubalis, 2n=50) chromosomes [J] . Pauciullo A, Perucatti A, Iannuzzi A, Journal of Applied Genetics . 2014,第3期

机译：开发具有13种特定于染色体的绘画探针的顺序多色FISH方法，以快速识别河水牛（Bubalus bubalis，2n = 50）染色体
3. Development and application of oligonucleotide-based chromosome painting for chromosome 4D of Triticum aestivum L. [J] . Chromosome research: An international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology . 2020,第2期

机译：基于寡核苷酸的核苷酸染色体涂料的染色体4D染色体涂料的研制与应用L.
4. FISH analysis of the arrangement of chromosomes in interphase nuclei using telomeric centromeric and DNA painting probes [C] . Shamci Monajembashi, Eberhard Schmitt, Heike Dittmar, Conference on optical biopsies and microscopic techniques . 1999

机译：用端粒焦质和DNA涂布探针分析核核晶体中染色体的排列分析
5. Development of pachytene cytogenetic fluorescence in situ hybridization (FISH) maps for six maize chromosomes: Insights into genome structure dynamics. [D] . Figueroa, Debbie. 2011

机译：六种玉米染色体的粗线细胞遗传荧光原位杂交（FISH）图的开发：对基因组结构动力学的洞察力。
6. Development and Applications of Chromosome-Specific Cytogenetic BAC-FISH Probes in S. spontaneum [O] . Guangrui Dong, Jiao Shen, Qing Zhang, -1

机译：自发链球菌染色体特异性细胞遗传学BAC-FISH探针的开发与应用
7. Development of a sequential multicolor-FISH approach with 13 chromosome-specific painting probes for the rapid identification of river buffalo (Bubalus bubalis, 2n = 50) chromosomes. [O] . Pauciullo A., Perucatti A., Iannuzzi A., 2014

机译：利用13种染色体特异性绘图探针开发连续多色FIsH方法，用于快速鉴定河水牛（Bubalus bubalis，2n = 50）染色体。

Reflections on the development and application of FISH whole chromosome painting

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