Photochemical genotoxicity: principles and test methods - Report of a GUM task force [Review]

Brendler-Schwaab S; Czich A; Epe B; Gocke E; Kaina B; Muller L

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Photochemical genotoxicity: principles and test methods - Report of a GUM task force [Review]

机译：光化学遗传毒性：原理和测试方法-GUM工作组的报告[评论]

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In recent years, assessing the photogenotoxic potential of a compound became an issue for certain drugs and cosmetical products. Therefore, existing methods performed according to international guidelines (e.g. OECD guidelines) were adapted to the use of concurrent UV-visible (UV-Vis) light irradiation for the assessment of photomutagenicity/photogenotoxicity. In this review, photobiological bases of the processes occurring in the cell after irradiation with UV- and/or visible (vis)-light as well as a compilation of testing methods is presented. Methods comprise cell free investigations on naked DNA and in vitro methods, such as the photo-Ames test, the photo-HPRT/photo-mouse lymphoma assay (MLA), the photo-micronucleus test (MNT), the photo-chromosomal aberration test (CA) and the photo-Cornet assay. A compilation of the currently available international literature of compounds tested on photogenotoxicity is given for each method. The state of the art of photogenotoxicity testing as well as the rational for testing are outlined in relation to the recommendations reached in expert working groups at different international meetings and to regulatory guidance papers. Finally, photogenotoxicity testing as predictor of photocarcinogenicity and in the light of risk assessment is discussed

机译：近年来，对于某些药物和化妆品，评估化合物的光遗传毒性潜力成为一个问题。因此，根据国际准则（例如OECD准则）执行的现有方法适用于同时使用紫外线-可见光（UV-Vis）照射来评估光致突变性/光遗传毒性。在这篇综述中，介绍了用紫外线和/或可见（可见）光照射后细胞中发生的过程的光生物学基础以及一系列测试方法。方法包括对裸露的DNA进行无细胞研究以及体外方法，例如photo-Ames试验，photo-HPRT / photo-mouse淋巴瘤试验（MLA），photo-micronucleus试验（MNT），photo-chromomalal畸变试验（CA）和光短号分析。每种方法都提供了有关光遗传毒性测试的化合物的当前国际可用文献的汇编。概述了光遗传毒性检测的最新技术以及检测的合理性，这些方法与专家工作组在不同的国际会议上达成的建议以及法规指导文件有关。最后，讨论了光遗传毒性测试作为光致癌性的预测指标并根据风险评估进行了讨论。

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《Mutation Research. Reviews in Mutation Research》 |2004年第1期|共27页
作者
Brendler-Schwaab S; Czich A; Epe B; Gocke E; Kaina B; Muller L;
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正文语种 eng
中图分类遗传学;
关键词
Photogenotoxicity; Photo-ames test; Photo-hprt assay; Photo-mouse; Chinese-hamster cells; Oxidative dna-damage; Photomutagenesis test; development; Hydroxyl radical scavengers; Near-ultraviolet light; Nru; phototoxicity test; Single-stranded-dna; In-vitro assessment; Salmonella-typhimurium; Visible-light;

机译：光遗传毒性;光-阿姆斯试验;光-hprt测定;光小鼠;中国仓鼠细胞;氧化性dna损伤;光诱变试验;发育;羟自由基清除剂;近紫外光;Nru;光毒性试验;单链-dna;体外评估;鼠伤寒沙门氏菌;可见光;

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1. Photochemical genotoxicity: principles and test methods - Report of a GUM task force [Review] [J] . Brendler-Schwaab S, Czich A, Epe B, Mutation Research. Reviews in Mutation Research . 2004,第1期

机译：光化学遗传毒性：原理和测试方法-GUM工作组的报告[评论]
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7. ACC/AHA 2002 guideline update for exercise testing: summary article A report of the American college of cardiology/American heart association task force on practice guidelines (committee to update the 1997 exercise testing guidelines) 11The ACC/AHA Task Force on Practice Guidelines makes every effort to avoid any actual or potential conflicts of interest that might arise as a result of an outside relationship or personal interest of a member of the writing panel. Specifically, all members of the writing panel are asked to provide disclosure statements of all such relationships that might be perceived as real or potential conflicts of interest. These statements are reviewed by the parent task force, reported orally to all members of the writing panel at the first meeting, and updated as changes occur.22This document was approved by the American College of Cardiology Foundation Board of Trustees in July 2002 and by the American Heart Association Science Advisory and Coordinating Committee in June 2002. When citing this document, the American College of Cardiology Foundation and the American Heart Association would appreciate the following citation format: Gibbons RJ, Balady GJ, Bricker JT, Chaitman BR, Fletcher GF, Froelicher VF, Mark DB, McCallister BD, Mooss AN, O’Reilly MG, Winters WL Jr. ACC/AHA 2002 guideline update for exercise testing: summary article: a report of the ACC/AHA Task Force on Practice Guidelines (Committee to Update the 1997 Exercise Testing Guidelines). J Am Coll Cardiol 2002;40:1531–40.33Copies: This document is available on the World Wide Web sites of the ACC (www.acc.org) and the AHA (www.americanheart.org). A single copy of the complete guidelines is available by calling 800-253-4636 (US only) or writing the American College of Cardiology, Resource Center, 9111 Old Georgetown Road, Bethesda, MD 20814-1699. Ask for reprint No. 71-0231. To obtain a copy of the Executive Summary published in the October 1, 2002 issue of Circulation, ask for reprint No. 71-0232. To purchase additional reprints (specify version and reprint number): up to 999 copies, call 800-611-6083 (US only) or fax 413-665-2671; 1000 or more copies, call 410-528-4426, fax 410-528-4264, or e-mail kbradle@lww.com.44(J Am Coll Cardiol 2002;40:1531–40.)55©2002 by the American College of Cardiology Foundation and the American Heart Association, Inc. [O] . Gibbons Raymond J, Balady Gary J, Timothy Bricker J, 2002

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Photochemical genotoxicity: principles and test methods - Report of a GUM task force [Review]

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