CYTOGENETIC EFFECTS IN THE PERIPHERAL LYMPHOCYTES AND KIDNEY CELLS OF RATS EXPOSED TO 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE (MX) ORALLY ON THREE CONSECUTIVE DAYS

Makipaakkanen J; Jansson K

首页> 外文期刊>Mutation research. Genetic toxicology testing >CYTOGENETIC EFFECTS IN THE PERIPHERAL LYMPHOCYTES AND KIDNEY CELLS OF RATS EXPOSED TO 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE (MX) ORALLY ON THREE CONSECUTIVE DAYS

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CYTOGENETIC EFFECTS IN THE PERIPHERAL LYMPHOCYTES AND KIDNEY CELLS OF RATS EXPOSED TO 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE (MX) ORALLY ON THREE CONSECUTIVE DAYS

机译：连续3天分别暴露于3-氯-4-（二氯甲基）-5-羟基-2（5H）-呋喃酮（MX）的大鼠外周血淋巴细胞和肾脏细胞的细胞遗传学效应

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We reported previously that 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), a chlorine disinfection by-product in drinking water, induces sister-chromatid exchanges (SCEs) in the peripheral lymphocytes of male and female rats after subchronic exposure. In the present study, we found that the peripheral lymphocytes of male rats exposed to MX (25-150 mg/kg) by gavage on three consecutive days showed a significant dose-related increase in chromosomal damage measured as micronuclei, in addition to SCEs. Moreover, MX produced a significant dose-related increase in SCEs in the kidney cells of the exposed rats. The magnitude of the genotoxic responses observed was relatively weak. The finding is, however, consistent with the known pharmacokinetic distribution of MX in the rat after oral dosing.

机译：我们以前曾报道过，饮用水中的氯消毒副产物3-chloro-4-（dichloromethyl）-5-hydroxy-2（5H）-呋喃酮（MX）诱导外周淋巴细胞中的姐妹染色单体交换（SCE）慢性暴露后的雄性和雌性大鼠的行为。在本研究中，我们发现，连续三天通过强饲法暴露于MX（25-150 mg / kg）的雄性大鼠的外周淋巴细胞，除SCE外，还显示了与微核有关的染色体损伤的剂量相关显着增加。此外，MX在暴露大鼠的肾细胞中导致SCE的剂量相关显着增加。观察到的遗传毒性反应的程度相对较弱。然而，该发现与口服给药后大鼠中MX的已知药代动力学分布一致。

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《Mutation research. Genetic toxicology testing》 |1995年第3期|共6页
作者
Makipaakkanen J; Jansson K;
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正文语种 eng
中图分类遗传学;
关键词
3 chloro 4 (dichloromethyl) 5 hydroxy 2(5h) furanone (mx); Potent bacterial mutagen; Drinking water; Invitro; Invivo; Mice; Acid;

机译：3氯4（二氯甲基）5羟基2（5h）呋喃酮（mx）;强力细菌诱变剂;饮用水;体外;体内;小鼠;酸;

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1. CYTOGENETIC EFFECTS IN THE PERIPHERAL LYMPHOCYTES AND KIDNEY CELLS OF RATS EXPOSED TO 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE (MX) ORALLY ON THREE CONSECUTIVE DAYS [J] . Makipaakkanen J, Jansson K Mutation research. Genetic toxicology testing . 1995,第2a3期

机译：连续3天分别暴露于3-氯-4-（二氯甲基）-5-羟基-2（5H）-呋喃酮（MX）的大鼠外周血淋巴细胞和肾脏细胞的细胞遗传学效应
2. Lack of induction of micronuclei in bone marrow erythrocytes of rats exposed to 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) for two years in a carcinogenicity bioassay. [J] . Jansson K Environmental and molecular mutagenesis. . 1998,第2期

机译：在两年的致癌性生物测定中，暴露于3-氯-4-（二氯甲基）-5-羟基-2（5H）-呋喃酮（MX）的大鼠骨髓红细胞中缺乏微核诱导。
3. Assessment of the genotoxicity of the rat carcinogen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in rat liver epithelial cells in vitro. [J] . Maki-Paakkanen J, Hakulinen P Toxicology in vitro: an international journal published in association with BIBRA . 2008,第2期

机译：评估大鼠致癌物3-氯-4-（二氯甲基）-5-羟基-2（5H）-呋喃酮（MX）在大鼠肝上皮细胞中的遗传毒性。
4. Pilot-plant study of the formaiton of the disinfection by-product 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in dinking water [C] . C.J.Hwang, S.W.Krasner, S.A.Andrews, Ozonation for drinking water treatment . 1992

机译：在饮用水中形成消毒副产物3-氯-4-（氯甲基）-5-羟基-2（5H）-呋喃酮（MX）的中试研究
5. Removal of 3-chloro-4-dichloromethyl-5-hydroxy-2(5H)-furanone (MX) Precursors during Water Treatment Biofiltration [D] . Mian, Noreen 2018

机译：水处理生物过滤过程中去除3-氯-4-二氯甲基-5-羟基-2（5H）-呋喃酮（MX）前体
6. 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) and mutagenic activity in Massachusetts drinking water. [O] . J Michael Wright, Joel Schwartz, Terttu Vartiainen, 2002

机译：马萨诸塞州饮用水中的3-Chloro-4-（dichloromethyl）-5-hydroxy-2（5H）-呋喃酮（MX）和诱变活性。
7. Experimental studies on cellular mechanisms of the carcinogenecity of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) (Kokeellisia tutkimuksia 3-kloori-4-(dikloorimetyyli)-5-hydroksi-2(5H)-furanonin (MX) karsinogeenisuuden solutason mekanismeista) [O] . Hakulinen Pasi 100

机译：3-氯-4-（二氯甲基）-5-羟基-2（5H） - 呋喃酮（mX）致癌性的实验研究（3-氯-4-（二氯甲基）-5-羟基-2的实验研究）（5H） - 呋喃酮（mX）致癌性的细胞机制）
8. Induction of Gastrointestinal Tract Nuclear Anomalies in B6C3F1 Mice by 3-Chloro-4-(Dichloromethyl)-5-Hydroxy-2(5H)-Furanone and 3,4-(Dichloro)-5-Hydroxy-2(5H)-Furanone, Mutagenic Byproducts of Chlorine Disinfection [R] . Daniel, F. B., Olson, G. R., Stober, J. A. 1991

机译：用3-氯-4-（二氯甲基）-5-羟基-2（5H） - 呋喃酮和3,4-（二氯）-5-羟基-2（5H） - 呋喃酮诱导B6C3F1小鼠胃肠道核异常，氯消毒的诱变副产物

CYTOGENETIC EFFECTS IN THE PERIPHERAL LYMPHOCYTES AND KIDNEY CELLS OF RATS EXPOSED TO 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE (MX) ORALLY ON THREE CONSECUTIVE DAYS

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