...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Mutation Research. Reviews in Mutation Research >Molecular epidemiology of breast cancer: genetic variation in steroid hormone metabolism
【24h】

Molecular epidemiology of breast cancer: genetic variation in steroid hormone metabolism

机译：乳腺癌的分子流行病学：类固醇激素代谢的遗传变异

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The age-specific incidence rate of breast cancer in women rises until menopause, levels off and then rises again at a much lower rate indicating a possible hormonal influence on the disease risk. A large amount of evidence has implicated hormones and other compounds with oestrogen activity in the pathogenesis of certain endocrine cancers, particularly breast cancer. Widely dispersed hormone-like chemicals, capable of disrupting the endocrine system and interfering with proliferation, have been described. Compounds such as dioxins, some polychlorinated biphenyls and the plastic ingredient bisphenol-A have been shown to interfere with human reproduction and hormonal regulation. The levels of these foreign compounds as well as the levels of endogenous oestradiol may influence the risk of breast cancer. Endogenous oestradiol is synthesised in the ovarian theca cells of premenopausal women or in the stromal adipose cells of the breast of postmenopausal women and mor quantities in peripheral tissue. These cells, as well as breast cancer tissue, express all the necessary enzymes for this synthesis: CYPI7, CYPlla, CYP19, hydroxysteroid hydrogenase, steroid sulphatase as well as enzymes further hydroxylating oestradiol such as CYPIA1, CYP3A4, CYPIB1. Potymorphisms in these enzymes may have a possible role in the link between environmental estrogens and hormone-like substances and the interindividual risk of breast cancer.
机译：女性乳腺癌的特定年龄发病率一直上升到更年期，然后趋于平稳，然后以低得多的比率再次上升，表明激素可能对疾病的风险产生影响。大量证据表明激素和其他具有雌激素活性的化合物与某些内分泌癌症，尤其是乳腺癌的发病机理有关。已经描述了能够破坏内分泌系统并干扰增殖的广泛分散的激素样化学物质。二恶英，某些多氯联苯和塑料成分双酚A等化合物已证明会干扰人类生殖和激素调节。这些外来化合物的水平以及内源性雌二醇的水平都可能影响乳腺癌的风险。内源性雌二醇是在绝经前妇女的卵巢卵泡膜细胞或绝经后妇女的乳房的基质脂肪细胞中合成的，在外周组织中的合成含量为零。这些细胞以及乳腺癌组织表达该合成所需的所有酶：CYPI7，CYPlla，CYP19，羟类固醇氢化酶，甾族硫酸酯酶以及进一步羟化雌二醇的酶，例如CYPIA1，CYP3A4，CYPIB1。这些酶的多态性可能在环境雌激素和激素样物质之间的关联以及个体间患乳腺癌的风险中可能起着作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号