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首页> 外文期刊>Molecular cancer therapeutics >Phytochemistry and pharmacogenomics of natural products derived from traditional Chinese medicine and Chinese materia medica with activity against tumor cells.
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Phytochemistry and pharmacogenomics of natural products derived from traditional Chinese medicine and Chinese materia medica with activity against tumor cells.

机译：具有抗肿瘤细胞活性的中药和中药天然产物的植物化学和药物基因组学。

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摘要

The cure from cancer is still not a reality for all patients, which is mainly due to the limitations of chemotherapy (e.g., drug resistance and toxicity). Apart from the high-throughput screening of synthetic chemical libraries, natural products represent attractive alternatives for drug development. We have done a systematic bioactivity-based screening of natural products derived from medicinal plants used in traditional Chinese medicine. Plant extracts with growth-inhibitory activity against tumor cells have been fractionated by chromatographic techniques. We have isolated the bioactive compounds and elucidated the chemical structures by nuclear magnetic resonance and mass spectrometry. By this strategy, we identified 25-O-acetyl-23,24-dihydro-cucurbitacin F as a cytotoxic constituent of Quisqualis indica. Another promising compound identified by this approach was miltirone from Salvia miltiorrhiza. The IC50 values for miltirone of 60 National Cancer Institute cell lines were associated with the microarray-based expression of 9,706 genes. By COMPARE and hierarchical cluster analyses, candidate genes were identified, which significantly predicted sensitivity or resistance of cell lines to miltirone.
机译：对于所有患者来说，仍然不能完全治愈癌症，这主要是由于化学疗法的局限性（例如，耐药性和毒性）。除了对合成化学文库进行高通量筛选外，天然产物还是药物开发的诱人替代品。我们已经对基于中药的药用植物天然产物进行了基于生物活性的系统筛选。通过色谱技术对具有对肿瘤细胞的生长抑制活性的植物提取物进行分级分离。我们已经通过核磁共振和质谱分离了生物活性化合物并阐明了化学结构。通过这种策略，我们确定25-O-乙酰基23,24-二氢葫芦素F是印度Quisqualis的细胞毒性成分。通过这种方法鉴定的另一种有希望的化合物是丹参中的米替农。 60种国家癌症研究所细胞系的米替农的IC50值与9706个基因的基于微阵列的表达有关。通过COMPARE和层次聚类分析，鉴定了候选基因，该基因显着预测了细胞株对米替农的敏感性或抗性。

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