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首页> 外文期刊>Molecular cell >Fragile X mental retardation protein regulates translation by binding directly to the ribosome
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Fragile X mental retardation protein regulates translation by binding directly to the ribosome

机译：脆性X智力低下蛋白通过直接结合核糖体来调节翻译

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摘要

Fragile X syndrome (FXS) is the most common form of inherited mental retardation, and it is caused by loss of function of the fragile X mental retardation protein (FMRP). FMRP is an RNA-binding protein that is involved in the translational regulation of several neuronal mRNAs. However, the precise mechanism of translational inhibition by FMRP is unknown. Here, we show that FMRP inhibits translation by binding directly to the L5 protein on the 80S ribosome. Furthermore, cryoelectron microscopic reconstruction of the 80S ribosome{dot operator}FMRP complex shows that FMRP binds within the intersubunit space of the ribosome such that it would preclude the binding of tRNA and translation elongation factors on the ribosome. These findings suggest that FMRP inhibits translation by blocking the essential components of the translational machinery from binding to the ribosome.
机译：脆性X综合征（FXS）是遗传性智力低下的最常见形式，它是由脆性X智力低下蛋白（FMRP）的功能丧失引起的。 FMRP是一种RNA结合蛋白，参与几种神经元mRNA的翻译调控。但是，FMRP抑制翻译的确切机制尚不清楚。在这里，我们显示FMRP通过直接结合80S核糖体上的L5蛋白来抑制翻译。此外，对80S核糖体的冷冻电子显微镜重建表明，FMRP结合在核糖体的亚基空间内，因此它将阻止tRNA和核糖体上翻译延伸因子的结合。这些发现表明，FMRP通过阻止翻译机制的必需成分与核糖体结合来抑制翻译。

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