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首页> 外文期刊>Molecular cancer therapeutics >Oncogenic viruses and tumor glucose metabolism: like kids in a candy store.
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Oncogenic viruses and tumor glucose metabolism: like kids in a candy store.

机译：致癌病毒和肿瘤葡萄糖代谢：就像糖果店里的孩子一样。

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摘要

Oncogenic viruses represent a significant public health burden in light of the multitude of malignancies that result from chronic or spontaneous viral infection and transformation. Although many of the molecular signaling pathways that underlie virus-mediated cellular transformation are known, the impact of these viruses on metabolic signaling and phenotype within proliferating tumor cells is less well understood. Whether the interaction of oncogenic viruses with metabolic signaling pathways involves enhanced glucose uptake and glycolysis (both hallmark features of transformed cells) or dysregulation of molecular pathways that regulate oxidative stress, viruses are adept at facilitating tumor expansion. Through their effects on cell proliferation pathways, such as the PI3K and MAPK pathways, the cell cycle regulatory proteins p53 and ATM, and the cell stress response proteins HIF-1alpha and AMPK, viruses exert control over critical metabolic signaling cascades. Additionally, oncogenic viruses modulate the tumor metabolomic profile through direct and indirect interactions with glucose transporters, such as GLUT1, and specific glycolytic enzymes, including pyruvate kinase, glucose 6-phosphate dehydrogenase, and hexokinase. Through these pathways, oncogenic viruses alter the phenotypic characteristics and energy-use methods of transformed cells; therefore, it may be possible to develop novel antiglycolytic therapies to target these dysregulated pathways in virus-derived malignancies.
机译：鉴于慢性或自发性病毒感染和转化所导致的众多恶性肿瘤，致癌病毒代表了巨大的公共卫生负担。尽管已知许多病毒介导的细胞转化基础的分子信号传导途径，但这些病毒对增殖肿瘤细胞内代谢信号传导和表型的影响尚不清楚。致癌病毒与代谢信号通路的相互作用是否涉及增强的葡萄糖摄取和糖酵解（均为转化细胞的标志性特征）或调节氧化应激的分子通路的失调，病毒都善于促进肿瘤的扩展。通过它们对细胞增殖途径（如PI3K和MAPK途径，细胞周期调节蛋白p53和ATM以及细胞应激反应蛋白HIF-1alpha和AMPK）的影响，病毒可以控制关​​键的代谢信号级联反应。另外，致癌病毒通过与葡萄糖转运蛋白（例如GLUT1）和特定糖酵解酶（包括丙酮酸激酶，6-磷酸葡萄糖脱氢酶和己糖激酶）的直接和间接相互作用来调节肿瘤的代谢组学特征。通过这些途径，致癌病毒改变了转化细胞的表型特征和能量利用方法。因此，可能有可能开发出新的抗糖酵解疗法来靶向病毒衍生的恶性肿瘤中这些失调的途径。

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