Cracking the Histone Code: One, Two, Three Methyls, You're Out!

Robert N. Dutnall

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Cracking the Histone Code: One, Two, Three Methyls, You're Out!

机译：破解组蛋白代码：一，二，三甲基，你出局了！

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In this issue of Molecular Cell, Zhang et al. report the structure of a ternary complex between the SET domain histone methyltransferase DIM-5, its cofactor, and a histone H3 peptide. The insight gained from analysis of a key amino acid provides an exciting opportunity to dissect the possible functional meaning of mono-, di-, and trimethylation of histone lysine residues in vivo that will complement existing approaches in the quest to crack the histone methylation code.

机译：在本期《分子细胞》中，Zhang等人。报道了SET域组蛋白甲基转移酶DIM-5，其辅因子和组蛋白H3肽之间的三元复合物的结构。从关键氨基酸的分析中获得的见识为剖析体内组蛋白赖氨酸残基的单，二和三甲基化的可能功能含义提供了令人兴奋的机会，这将补充寻求破解组蛋白甲基化密码的现有方法。

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《Molecular cell》 |2003年第1期|共2页
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Robert N. Dutnall;
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1. Cracking the Histone Code: One, Two, Three Methyls, You're Out! [J] . Robert N. Dutnall Molecular cell . 2003,第1期

机译：破解组蛋白代码：一，二，三甲基，你出局了！
2. Cracking the survival code Autophagy-related histone modifications [J] . Fullgrabe Jens, Heldring Nina, Hermanson Ola, Autophagy . 2014,第4期

机译：破解生存码自噬相关的组蛋白修改
3. Cracking the survival code Autophagy-related histone modifications [J] . Fullgrabe Jens, Heldring Nina, Hermanson Ola, Autophagy . 2014,第4期

机译：破解生存码自噬相关的组蛋白修改
4. Cracking the Histone Code: a Mass Spectrometry Based Approach for the Determination of Histone Modifications [C] . Michael A. Freitas International Symposium on Runaway Reactions, Pressure Relief Design and Effluent Handling American Institute of Chemical Engineers/American Chemical Society Management Conference . 2005

机译：裂解组蛋白代码：基于质谱的基于质谱法测定组蛋白修饰的方法
5. I. Helical templating of oligopeptides by cyclodextrin-based receptors. II. Cracking the histone code: Oligopeptides as selective agents in histone deacetylase inhibition. [D] . Wilson, David Meybin. 2003

机译：I.基于环糊精的受体的螺旋螺旋寡肽。二。破解组蛋白密码：寡肽作为组蛋白脱乙酰基酶抑制作用的选择剂。
6. PDTM-39. CRACKING THE HISTONE CODE: REVEALING THERAPEUTIC EPIGENETIC TARGETS THROUGH HISTONE H3 TAIL ANALYSIS OF DIFFUSE INTRINSIC PONTINE GLIOMA [O] . Daphne Li, Tina Huang, Jeannie Camarillo, 2019

机译：PDTM-39。通过组蛋白H3尾部分析揭示组蛋白代码：通过组蛋白H3尾部分析揭示治疗性表展靶标
7. A Global View of DNA-Packing Proteins Cracks the Histone Code [O] . 100

机译：DNA包装蛋白的全局视图破解了组蛋白密码
8. Histone Code Modulation by Oncogenic PWWP-Domain Protein in Breast Cancers. [R] . Yang, Z. 2014

机译：组织代码调节致癌pWWp域蛋白在乳腺癌。

Cracking the Histone Code: One, Two, Three Methyls, You're Out!

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