Structural basis of the ribosomal machinery for Peptide bond formation, translocation, and nascent chain progression.

Bashan A; Agmon I; Zarivach R; Schluenzen F; Harms J; Berisio R; Bartels H; Franceschi F; Auerbach T; Hansen HA; Kossoy E; Kessler M; Yonath A

首页> 外文期刊>Molecular cell >Structural basis of the ribosomal machinery for Peptide bond formation, translocation, and nascent chain progression.

【24h】

Structural basis of the ribosomal machinery for Peptide bond formation, translocation, and nascent chain progression.

机译：肽键形成，易位和新生链进展的核糖体机器的结构基础。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Crystal structures of tRNA mimics complexed with the large ribosomal subunit of Deinococcus radiodurans indicate that remote interactions determine the precise orientation of tRNA in the peptidyl-transferase center (PTC). The PTC tolerates various orientations of puromycin derivatives and its flexibility allows the conformational rearrangements required for peptide-bond formation. Sparsomycin binds to A2602 and alters the PTC conformation. H69, the intersubunit-bridge connecting the PTC and decoding site, may also participate in tRNA placement and translocation. A spiral rotation of the 3' end of the A-site tRNA around a 2-fold axis of symmetry identified within the PTC suggests a unified ribosomal machinery for peptide-bond formation, A-to-P-site translocation, and entrance of nascent proteins into the exit tunnel. Similar 2-fold related regions, detected in all known structures of large ribosomal subunits, indicate the universality of this mechanism.

机译：tRNA模拟物的晶体结构与Deducoccus radiodurans的大核糖体亚基复合，表明远程相互作用决定了tRNA在肽基转移酶中心（PTC）中的精确定向。 PTC耐受嘌呤霉素衍生物的各种方向，其柔韧性允许肽键形成所需的构象重排。稀疏霉素与A2602结合并改变PTC构象。 H69是连接PTC和解码位点的亚基间桥，也可能参与tRNA的放置和转运。 A位点tRNA的3'端围绕PTC内对称的2倍对称轴螺旋旋转表明肽核键形成，A位到P位易位和新生进入的统一核糖体机制蛋白质进入出口通道。在大的核糖体亚基的所有已知结构中检测到的相似的2倍相关区域表明该机制的普遍性。

著录项

来源
《Molecular cell》 |2003年第1期|共12页
作者
Bashan A; Agmon I; Zarivach R; Schluenzen F; Harms J; Berisio R; Bartels H; Franceschi F; Auerbach T; Hansen HA; Kossoy E; Kessler M; Yonath A;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类分子生物学;细胞生物学;
关键词
Oncogene; RET; Protein translocation; RNA; Transfer; Peptides; Industrial machine; NOS; RNA; 转移; 肽类;

机译：Oncogene;RET;Protein translocation;RNA;Transfer;Peptides;Industrial machine;NOS;RNA;转移;肽类;

相似文献

外文文献
中文文献
专利

1. Structural basis of the ribosomal machinery for Peptide bond formation, translocation, and nascent chain progression. [J] . Bashan A, Agmon I, Zarivach R, Molecular cell . 2003,第1期

机译：肽键形成，易位和新生链进展的核糖体机器的结构基础。
2. Perspectives and Insights into the Competition for Aminoacyl-tRNAs between the Translational Machinery and for tRNA Dependent Non-Ribosomal Peptide Bond Formation [J] . Angela W. S. Fung, Roshani Payoe, Richard P. Fahlman Life . 2016,第1期

机译：转化机器之间的氨酰基-tRNA竞争和依赖tRNA的非核糖体肽键形成竞争的观点和见解
3. Perspectives and Insights into the Competition for Aminoacyl-tRNAs between the Translational Machinery and for tRNA Dependent Non-Ribosomal Peptide Bond Formation [J] . Adrian Gabriel Torres, Angela W. S. Fung, Llu#xED, Life . 2015,第1期

机译：转化机器之间的氨酰基-tRNA竞争和依赖tRNA的非核糖体肽键形成竞争的观点和见解
4. A MULTISCALE APPROACH TO SAMPLING NASCENT PEPTIDE CHAINS IN THE RIBOSOMAL EXIT TUNNEL [C] . V. A. VOELZ, P. PETRONE, V. S. PANDE PSB;Pacific symposium on biocomputing; 20090105-09;20090105-09; Kohala Coast, HI(US);Kohala Coast, HI(US) . 2009

机译：核糖体出口隧道中新肽链采样的多尺度方法
5. Origins of translation machinery: Aminoacylation of minimalist tRNA(leu) molecules and non-ribosomal peptide bond formation. [D] . Larkin, Deana Christine. 2001

机译：翻译机制的起源：极简tRNA（leu）分子的氨基酰化作用和非核糖体肽键的形成。
6. Perspectives and Insights into the Competition for Aminoacyl-tRNAs between the Translational Machinery and for tRNA Dependent Non-Ribosomal Peptide Bond Formation [O] . Angela W. S. Fung, Roshani Payoe, Richard P. Fahlman 2016

机译：转化机器之间的氨酰基-tRNA竞争和依赖tRNA的非核糖体肽键形成竞争的观点和见解
7. On the structural basis of peptide-bond formation and antibiotic resistance from atomic structures of the large ribosomal subunit [O] . Steitz Thomas A. 2005

机译：基于核糖体大亚基原子结构的肽键形成和抗生素抗性的结构基础

Structural basis of the ribosomal machinery for Peptide bond formation, translocation, and nascent chain progression.

摘要

著录项

相似文献

相关主题

期刊订阅