Human telomeres have different overhang sizes at leading versus lagging strands

Chai WH; Du Q; Shay JW; Wright WE

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Human telomeres have different overhang sizes at leading versus lagging strands

机译：人类端粒在前导链和滞后链上具有不同的突出端大小

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G-rich 3' telomeric overhangs are required both for forming the distinct telomere structures to protect chromosome ends and for extending telomeres by telomerase. However, little is known about the molecular mechanisms generating telomere overhangs in human cells. We show here that cultured normal human diploid cells have longer G overhangs at telomeres generated by lagging-strand synthesis than by leading-strand synthesis. We also demonstrate that telomerase expression results in elongated overhangs at the leading daughter telomeres. Thus, the overhangs at the leading and lagging daughter telomeres are generated differently in human cells, and telomerase may preferentially affect overhangs generated at the telomeres produced by leading-strand synthesis.

机译：富含G的3'端粒突出端既需要形成独特的端粒结构以保护染色体末端，又需要通过端粒酶延伸端粒。然而，关于在人类细胞中产生端粒突出端的分子机制知之甚少。我们在这里显示，培养的正常人二倍体细胞在由落后链合成产生的端粒比由领先链合成产生的端粒上具有更长的G突出端。我们还证明端粒酶的表达导致在领先的子级端粒延长悬伸。因此，在人类细胞中，前导子链和滞后子链端粒的突出端以不同的方式产生，端粒酶可优先影响由前导链合成产生的端粒的突出端。

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《Molecular cell》 |2006年第3期|共9页
作者
Chai WH; Du Q; Shay JW; Wright WE;
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正文语种 eng
中图分类分子生物学;
关键词
DNA-DAMAGE RESPONSE; MAMMALIAN TELOMERES; HUMAN-CHROMOSOMES; C-STRAND; SACCHAROMYCES-CEREVISIAE; REPLICATIVE SENESCENCE; CELLULAR SENESCENCE; END REPLICATION; T-LOOPS; G-TAILS;

机译：DNA损伤反应;哺乳动物端粒;人类染色体;C-级;糖酵母-蜡染;复制性敏感性;细胞敏感性;末端复制;T环;G-尾;

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机译：人类端粒在前导链和滞后链上具有不同的突出端大小
2. Human Stn1 protects telomere integrity by promoting efficient lagging-strand synthesis at telomeres and mediating C-strand fill-in [J] . Chenhui Huang, Xueyu Dai, Weihang Chai Cell research. . 2012,第12期

机译：Human Stn1通过促进端粒有效的滞后链合成和介导C链填充来保护端粒完整性
3. Human Stn1 protects telomere integrity by promoting efficient lagging-strand synthesis at telomeres and mediating C-strand fill-in [J] . Chenhui Huang, Xueyu Dai, Weihang Chai 细胞研究（英文版） . 2012,第012期

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5. The DNA polymerase III holoenzyme: An asymmetric dimeric replicative complex containing distinguishable leading and lagging strand polymerases. [D] . Glover, Bradley P. 2001

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6. CDK1 differentially regulates G-overhang generation at leading- and lagging-strand telomeres in telomerase-negative cells in G2 phase [O] . Xueyu Dai, Chenhui Huang, Weihang Chai 2012

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Human telomeres have different overhang sizes at leading versus lagging strands

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