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首页> 外文期刊>Molecular cell >Two actin-related proteins are shared functional components of the chromatin-remodeling complexes RSC and SWI/SNF.
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Two actin-related proteins are shared functional components of the chromatin-remodeling complexes RSC and SWI/SNF.

机译：两个肌动蛋白相关蛋白是染色质重塑复合物RSC和SWI / SNF的共有功能组件。

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摘要

The yeast Saccharomyces cerevisiae contains two related chromatin-remodeling complexes, RSC and SWI/SNF, which are shown to share the actin-related proteins Arp7 and Arp9. Depending on the genetic background tested, arp7 delta and arp9 delta mutants are either inviable or show greatly impaired growth and Swi-/Snf- mutant phenotypes. Unlike swi/snf mutants, viable arp7 delta or arp9 delta mutants have an Spt- phenotype, suggesting that RSC affects transcription. Temperature-sensitive mutations in ARP7 and ARP9 were isolated, and the amino acid changes support the structural relationship of Arp7 and Arp9 to actin. However, site-directed mutations predicted to impair ATP binding or hydrolysis did not detectably affect Arp7 or Arp9 function. Our results suggest that actin-related proteins perform important roles in chromatin-remodeling complexes by virtue of structural rather than enzymatic similarities to actin.
机译：酵母酿酒酵母包含两个相关的染色质重塑复合物，RSC和SWI / SNF，它们显示与肌动蛋白相关的蛋白Arp7和Arp9共享。根据所测试的遗传背景，arp7 delta和arp9 delta突变体要么无法生存，要么显示出严重受损的生长和Swi- / Snf-突变体表型。与swi / snf突变体不同，可行的arp7 delta或arp9 delta突变体具有Spt表型，表明RSC影响转录。 ARP7和ARP9的温度敏感突变被分离，并且氨基酸变化支持Arp7和Arp9与肌动蛋白的结构关系。但是，定点突变预计会破坏ATP结合或水解不会可检测地影响Arp7或Arp9的功能。我们的结果表明，肌动蛋白相关蛋白由于与肌动蛋白的结构相似而不是酶促相似，因此在染色质重塑复合体中起重要作用。

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