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首页> 外文期刊>Molecular reproduction and development >Loss of Runx3 affects ovulation and estrogen-induced endometrial cell proliferation in female mice.
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Loss of Runx3 affects ovulation and estrogen-induced endometrial cell proliferation in female mice.

机译：Runx3的损失影响雌性小鼠的排卵和雌激素诱导的子宫内膜细胞增殖。

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摘要

Runx3 is a transcription factor that belongs to the Runx family. We studied the function of Runx3 in the mouse ovary and uterus using the Runx3 knockout (Runx3(-/-)) mouse. Ovaries were collected from 8-week-old wild type (wt) and Runx3(-/-) mice. Histological studies showed that follicles were present at various developmental stages in the Runx3(-/-) and wt mouse ovaries. The numbers of primary, preantral and antral follicles in the Runx3(-/-) mice were significantly less than those in the wt mice while the number of primordial follicles in the Runx3(-/-) mice was not significantly different from that in the wt mice. Corpora lutea were not detected in the Runx3(-/-) mouse ovary. Gonadotropin treatment in immature female mice induced ovulation in Runx3(-/-) mice as well as in wt mice, indicating that ovaries of Runx3(-/-) mice respond to gonadotropin treatment as those in wt mouse ovaries. This suggests that failure of ovulation is due to dysfunction of regulatory mechanism of gonadotropin secretion. In addition, the uteri of Runx3(-/-) mice were atrophic, showed thin epithelial layers compared with those of the wt mice, and did not respond to estrogen in terms of DNA replication in endometrial epithelial cells. These results suggest that Runx3 takes part in the regulation of reproductive functions.
机译：Runx3是属于Runx家族的转录因子。我们使用Runx3基因敲除（Runx3（-/-））小鼠研究了Runx3在小鼠卵巢和子宫中的功能。从8周龄野生型（wt）和Runx3（-/-）小鼠中收集卵巢。组织学研究表明，在Runx3（-/-）和wt小鼠卵巢的各个发育阶段都存在卵泡。 Runx3（-/-）小鼠的初级，卵前和窦前卵泡数量明显少于wt小鼠，而Runx3（-/-）小鼠的原始卵泡数量与正常小鼠无显着差异。 wt小鼠。在Runx3（-/-）小鼠卵巢中未检测到黄体。促性腺激素治疗在未成熟雌性小鼠中引起Runx3（-/-）小鼠以及wt小鼠排卵，这表明Runx3（-/-）小鼠的卵巢与wt小鼠卵巢中的雌性激素反应。这表明排卵失败是由于促性腺激素分泌调节机制的功能障碍所致。此外，Runx3（-/-）小鼠的子宫是萎缩的，与wt小鼠相比子宫上皮薄，并且在子宫内膜上皮细胞中的DNA复制方面对雌激素无反应。这些结果表明Runx3参与了生殖功能的调节。

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