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首页> 外文期刊>Molecular reproduction and development >X-irradiation--induced changes in the progression of type B spermatogonia and preleptotene spermatocytes.
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X-irradiation--induced changes in the progression of type B spermatogonia and preleptotene spermatocytes.

机译：X射线辐射-引起B型精原细胞和前瘦素精细胞进展的变化。

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摘要

In response to induced DNA damage, proliferating cells arrest in their cell cycle or go into apoptosis. Ionizing radiation is known to induce degeneration of mammalian male germ cells. The effects on cell-cycle progression, however, have not been thoroughly studied due to lack of methods for identifying effects on a particular cell-cycle phase of a specific germ cell type. In this study, we have utilized the technique for isolation of defined segments of seminiferous tubules to examine the cell-cycle progression of irradiated rat mitotic (type B spermatogonia) and meiotic (preleptotene spermatocytes) G1/S cells. Cells irradiated as type B spermatogonia in mitotic S phase showed a small delay in progression through meiosis. Thus, it seems that transient arrest in the progression can occur in the otherwise strictly regulated progression of germ cells in the seminiferous epithelium. Contrary to the arrest observed in type B spermatogonia and in previous studies on somatic cells, X-irradiation did not result in a G1 delay in meiotic cells. This lack of arrest occurred despite the presence of unrepaired DNA damage that was measured when the cells had progressed through the two meiotic divisions.
机译：响应诱导的DNA损伤，增殖细胞停滞在其细胞周期中或进入凋亡状态。已知电离辐射诱导哺乳动物雄性生殖细胞的变性。但是，由于缺乏确定对特定生殖细胞类型的特定细胞周期阶段的影响的方法，因此尚未对细胞周期进程的影响进行彻底研究。在这项研究中，我们已经利用分离生精小管的确定片段的技术来检查辐射的大鼠有丝分裂（B型精原细胞）和减数分裂（前瘦素精细胞）G1 / S细胞的细胞周期进程。在有丝分裂S期照射为B型精原细胞的细胞在减数分裂过程中显示出少量延迟。因此，似乎在进展过程中的瞬时停滞可以发生在生精上皮中生殖细胞的本来受到严格调节的进展中。与在B型精原细胞和先前对体细胞的研究中观察到的阻滞相反，X射线辐射并未导致减数分裂细胞中的G1延迟。尽管存在未修复的DNA损伤，但仍存在这种停滞现象，这是通过细胞通过两个减数分裂分裂而测得的。

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