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首页> 外文期刊>Cancer: A Journal of the American Cancer Society >Biospecimen Reporting for Improved Study Quality (BRISQ)
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Biospecimen Reporting for Improved Study Quality (BRISQ)

机译：生物标本报告以提高研究质量（BRISQ）

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摘要

Human biospecimens are subjected to collection, processing, and storage that can significantly alter their molecular composition and consistency. These biospecimen preanalytical factors, in turn, influence experimental outcomes and the ability to reproduce scientific results. Currently, the extent and type of information specific to the biospecimen preanalytical conditions reported in scientific publications and regulatory submissions varies widely. To improve the quality of research that uses human tissues, it is crucial that information on the handling of biospecimens be reported in a thorough, accurate, and standardized manner. The Biospecimen Reporting for Improved Study Quality (BRISQ) recommendations outlined herein are intended to apply to any study in which human biospecimens are used. The purpose of reporting these details is to supply others, from researchers to regulators, with more consistent and standardized information to better evaluate, interpret, compare, and reproduce the experimental results. The BRISQ guidelines are proposed as an important and timely resource tool to strengthen communication and publications on biospecimen-related research and to help reassure patient contributors and the advocacy community that their contributions are valued and respected.
机译：人类生物标本经过收集，加工和储存，可能会大大改变其分子组成和一致性。这些生物样本的分析前因素反过来会影响实验结果和再现科学结果的能力。当前，科学出版物和法规文件中报告的针对生物样本分析前条件的信息的范围和类型差异很大。为了提高利用人体组织的研究质量，至关重要的是要以彻底，准确和标准化的方式报告有关生物样本处理的信息。本文概述的《提高生物质量的生物样品报告》（BRISQ）建议旨在适用于使用人类生物样品的任何研究。报告这些详细信息的目的是为其他人员（从研究人员到监管机构）提供更一致和标准化的信息，以更好地评估，解释，比较和复制实验结果。建议将BRISQ指南作为重要且及时的资源工具，以加强与生物样本相关研究的交流和出版物，并帮助向患者贡献者和倡导者保证他们的贡献受到重视和尊重。

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