Desensitization of an adult patient with Pompe disease and a history of anaphylaxis to alglucosidase alfa.

Lipinski SE; Lipinski MJ; Burnette A

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Desensitization of an adult patient with Pompe disease and a history of anaphylaxis to alglucosidase alfa.

机译：一名成人庞贝病患者的脱敏和过敏反应史的α葡糖苷酶。

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We report on the successful desensitization of an adult female with Pompe disease who had previously experienced anaphylaxis to intravenous alglucosidase alfa therapy. The starting alglucosidase alfa dose for desensitization was 10mg/kg with gradual dose escalation and desensitization via serial dilution was completed over five infusions. This methodology serves as a means to desensitize patients with prior anaphylactic response to alglucosidase alfa so that enzyme replacement therapy can be utilized.

机译：我们报道了庞培病成年女性的成功脱敏，该女性以前曾对静脉内葡糖苷酶α疗法有过敏反应。用于脱敏的起始葡糖苷酶α剂量为10mg / kg，并逐渐增加剂量，并通过连续稀释五次输注完成脱敏。该方法学作为一种手段，可以使对先前对α-葡糖苷酶有过敏性反应的患者脱敏，从而可以利用酶替代疗法。

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《Molecular genetics and metabolism》 |2009年第3期|共3页
作者
Lipinski SE; Lipinski MJ; Burnette A;
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正文语种 eng
中图分类医学遗传学;内分泌腺疾病及代谢病;
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1. Desensitization of an adult patient with Pompe disease and a history of anaphylaxis to alglucosidase alfa. [J] . Lipinski SE, Lipinski MJ, Burnette A Molecular genetics and metabolism . 2009,第3期

机译：一名成人庞贝病患者的脱敏和过敏反应史的α葡糖苷酶。
2. Desensitization of two young patients with infantile-onset Pompe disease and severe reactions to alglucosidase alfa [J] . Gragnaniello V., Fecarotta S., Pecoraro A., Neurological sciences . 2019,第7期

机译：两种幼儿发病型POPPE疾病患者的脱敏，对alglucosidase Alfa的严重反应
3. A CASE OF SUCCESSFUL DESENSITIZATION TO ALGLUCOSIDASE ALFA IN A 7 WEEK-OLD WITH INFANTILE-ONSET POMPE DISEASE. [J] . Adkins C., Makris C. M., Kankirawatana S. Annals of allergy, asthma, and immunology . 2014,第5Suppla1期

机译：在7周大的小儿发作性庞氏病中成功使葡糖苷酶α脱敏的情况。
4. Predicting high-risk prognosis from diagnostic histories of adult disease patients via deep recurrent neural networks [C] . Jung-Woo Ha, Adrian Kim, Dongwon Kim, 2017 IEEE International Conference on Big Data and Smart Computing . 2017

机译：通过深度循环神经网络从成人疾病患者的诊断历史预测高危预后
5. A Skeletal Muscle Model of Infantile-onset Pompe Disease with Patient-specific iPS Cells [D] . Yoshida, Takeshi 2019

机译：患儿特异性iPS细胞的小儿发作性庞贝病的骨骼肌模型
6. An individually modified approach to desensitize infants and young children with Pompe disease and significant reactions to alglucosidase alfa infusions [O] . Areeg H. El-Gharbawy, Joanne Mackey, Stephanie DeArmey, -1

机译：一种单独的修饰方法脱敏的婴儿和幼儿患有Pompe疾病的幼儿以及对alglucosidase Alfa输注的显着反应
7. An individually, modified approach to desensitize infants and young children with Pompe disease, and significant reactions to alglucosidase alfa infusions [O] . Areeg H. El-Gharbawy, Joanne Mackey, Stephanie DeArmey, 2011

机译：一种单独的修饰方法，脱敏的婴儿和幼儿患有Pompe疾病的幼儿，以及对alglucosidase Alfa输注的显着反应

Desensitization of an adult patient with Pompe disease and a history of anaphylaxis to alglucosidase alfa.

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