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首页> 外文期刊>Nano letters >Silica-coated gold nanorods as photoacoustic signal nanoamplifiers
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Silica-coated gold nanorods as photoacoustic signal nanoamplifiers

机译：二氧化硅涂层的金纳米棒作为光声信号纳米放大器

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Photoacoustic signal generation by metal nanoparticles relies on the efficient conversion of light to heat, its transfer to the environment, and the production of pressure transients. In this study we demonstrate that a dielectric shell has a strong influence on the amplitude of the generated photoacoustic signal and that silica-coated gold nanorods of the same optical density are capable of producing about 3-fold higher photoacoustic signals than nanorods without silica coating. Spectrophotometry measurements and finite difference time domain (FDTD) analysis of gold nanorods before and after silica coating showed only an insignificant change of the extinction and absorption cross sections, hence indicating that the enhancement is not attributable to changes in absorption cross section resulting from the silica coating. Several factors including the silica thickness, the gold/silica interface, and the surrounding solvent were varied to investigate their effect on the photoacoustic signal produced from silica-coated gold nanorods. The results suggest that the enhancement is caused by the reduction of the gold interfacial thermal resistance with the solvent due to the silica coating. The strong contrast enhancement in photoacoustic imaging, demonstrated using phantoms with silica-coated nanorods, shows that these hybrid particles acting as "photoacoustic nanoamplifiers" are high efficiency contrast agents for photoacoustic imaging or photoacoustic image-guided therapy.
机译：金属纳米粒子产生的光声信号依赖于光到热的有效转化，光到环境的传递以及瞬态压力的产生。在这项研究中，我们证明了介电壳对所产生的光声信号的幅度有很强的影响，并且具有相同光密度的二氧化硅涂层的金纳米棒能够产生比没有二氧化硅涂层的纳米棒高约3倍的光声信号。二氧化硅涂覆前后金纳米棒的分光光度法测量和有限差分时域（FDTD）分析显示消光和吸收截面的变化很小，因此表明这种增强不归因于二氧化硅引起的吸收截面的变化涂层。改变了二氧化硅的厚度，金/二氧化硅界面和周围的溶剂等几个因素，以研究它们对由二氧化硅包覆的金纳米棒产生的光声信号的影响。结果表明，这种增强是由于二氧化硅涂层导致金与溶剂的界面热阻降低所致。使用带有二氧化硅涂层的纳米棒的体模展示的在光声成像中的强烈对比度增强表明，这些杂化颗粒充当“光声纳米放大器”，是用于光声成像或光声图像引导疗法的高效造影剂。

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