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Biodegradable mesostructured polymer membranes

机译：可生物降解的介孔结构聚合物膜

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摘要

The extracellular matrix (ECM) has a quasi-ordered reticular mesostructure with feature sizes on the order of tenths of to a few hundred nanometers. Approaches to preparing biodegradable synthetic scaffolds for engineered tissues that have the critical mesostructure to mimic ECM are few. Here we present a simple and general solvent evaporation-induced self-assembly (EISA) approach to preparing concentrically reticular mesostructured polyol-polyester membranes. The mesostructures were formed by a novel self-assembly process without covalent or electrostatic interactions, which yielded feature sizes matching those of ECM. The mesostructured materials were nonionic, hydrophilic, and water-permeable and could be shaped into arbitrary geometries such as conformally molded tubular sacs and micropatterned meshes. Importantly, the mesostructured polymers were biodegradable and were used as ultrathin temporary substrates for engineering vascular tissue constructs.
机译：细胞外基质（ECM）具有准序的网状介观结构，其特征尺寸在十分之一到几百纳米之间。制备具有可模仿ECM的关键介观结构的工程组织的可生物降解合成支架的方法很少。在这里，我们提出了一种简单而通用的溶剂蒸发诱导自组装（EISA）方法来制备同心网状介孔结构多元醇-聚酯膜。介孔结构是通过新型的自组装过程形成的，没有共价或静电相互作用，产生的特征尺寸与ECM相匹配。介孔结构材料是非离子的，亲水的和水可渗透的，并且可以成形为任意几何形状，例如保形模制的管状囊和微图案的网孔。重要的是，介孔结构的聚合物是可生物降解的，并被用作工程血管组织构造的超薄临时底物。

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