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Wide varieties of cationic nanoparticles induce defects in supported lipid bilayers

机译：种类繁多的阳离子纳米颗粒会诱导脂质双分子层的缺陷

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摘要

Nanoparticles with widely varying physical properties and origins (spherical versus irregular, synthetic versus biological, organic versus inorganic, flexible versus rigid, small versus large) have been previously noted to translocate across the cell plasma membrane. We have employed atomic force microscopy to determine if the physical disruption of lipid membranes, formation of holes and/or thinned regions, is a common mechanism of interaction between these nanoparticles and lipids. It was found that a wide variety of nanoparticles, including a cell penetrating pepide (MSI-78), a protein (TAT), polycationic polymers (PAMAM dendrimers, pentanol-core PAMAM dendrons, polyethyleneimine, and diethylaminoethyl-dextran), and two inorganic particles (Au-NH2, SiO2-NH2), can induce disruption, including the formation of holes, membrane thinning, and/or membrane erosion, in supported lipid bilayers.
机译：先前已经注意到具有广泛变化的物理性质和来源（球形与不规则，合成与生物，有机与无机，柔性与刚性，小与大）的纳米粒子可跨细胞质膜移位。我们已经使用原子力显微镜来确定脂质膜的物理破坏，孔的形成和/或变薄的区域是否是这些纳米颗粒和脂质之间相互作用的常见机制。已发现各种各样的纳米粒子，包括细胞穿透肽（MSI-78），蛋白质（TAT），聚阳离子聚合物（PAMAM树状大分子，戊醇核PAMAM树状大分子，聚乙烯亚胺和二乙氨基乙基-右旋糖酐）和两种无机颗粒（Au-NH2，SiO2-NH2）可以在支持的脂质双层中诱导破坏，包括形成孔，膜变薄和/或膜腐蚀。

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