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Identity profiling of cell surface markers by multiplex gold nanorod probes

机译:通过多重金纳米棒探针对细胞表面标志物进行身份分析

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摘要

Gold nanorod molecular probes (GNrMPs) were designed and fabricated for multiplex identification of cell surface markers in HBECs. Cells were probed directly using dark field microscopy integrated with a spectral imager for simultaneous detection of up to three surface markers. The immunophenotype composition of these cell lines indicative of their metastasis potential was assessed using the GNrMPs. The technique has the potential to become an important tool for diagnosis and prognosis of breast and other cancers.
机译:设计和制造了金纳米棒分子探针(GNrMPs),用于HBEC中细胞表面标记物的多重鉴定。使用与光谱成像仪集成的暗视野显微镜直接探测细胞,以同时检测多达三个表面标记。使用GNrMPs评估了指示其转移潜力的这些细胞系的免疫表型组成。该技术有可能成为乳腺癌和其他癌症的诊断和预后的重要工具。

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