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Size and surface effects on the MRI relaxivity of manganese ferrite nanoparticle contrast agents

机译：尺寸和表面对锰铁氧体纳米粒子造影剂MRI弛豫性的影响

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Superparamagnetic MnFe2O4 nanocrystals of different sizes were synthesized in high-boiling ether solvent and transferred into water using three different approaches. First, we applied a ligand exchange in order to form a water soluble polymer shell. Second, the particles were embedded into an amphiphilic polymer shell. Third, the nanoparticles were embedded into large micelles formed by lipids. Although all approaches lead to effective negative contrast enhancement, we observed significant differences concerning the magnitude of this effect. The transverse relaxivity, in particular r(2)*, is greatly higher for the micellar system compared to the polymer-coated particles using same-sized nanoparticles. We also observed an increase in transverse relaxivities with increasing particle size for the polymer-coated nanocrystals. The results are qualitatively compared with theoretical models describing the dependence of relaxivity on the size of magnetic spheres.
机译：在高沸点醚溶剂中合成了不同尺寸的超顺磁性MnFe2O4纳米晶体，并使用三种不同的方法将其转移到水中。首先，我们进行了配体交换，以形成水溶性聚合物壳。第二，将颗粒嵌入两亲性聚合物壳中。第三，将纳米颗粒嵌入由脂质形成的大胶束中。尽管所有方法都可以有效地增强负对比度，但我们观察到这种效果的程度存在明显差异。与使用相同尺寸的纳米颗粒的聚合物涂层颗粒相比，胶束系统的横向弛豫性，特别是r（2）*更高。我们还观察到，聚合物包覆的纳米晶体的横向弛豫性随粒径的增加而增加。将结果与描述松弛度对磁球尺寸的依赖性的理论模型进行定性比较。

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