Gadonanotubes as ultrasensitive pH-smart probes for magnetic resonance imaging

Hartman KB; Laus S; Bolskar RD; Muthupillai R; Helm L; Toth E; Merbach AE; Wilson LJ

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Gadonanotubes as ultrasensitive pH-smart probes for magnetic resonance imaging

机译：Gadonanotubes作为用于磁共振成像的超灵敏pH值智能探针

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With their nanoscalar, superparamagnetic Gd3+-ion clusters (11 x 5 nm) confined within ultrashort (20-80 nm) single-walled carbon nanotube capsules, gadonanotubes are high-performance T-1-weighted contrast agents for magnetic resonance imaging (MRI). At 1.5 T, 37 degrees C, and pH 6.5, the r(1) relaxivity (ca. 180 mM(-1) s(-1) per Gd3+ ion) of gadonanotubes is 40 times greater than any current Gd3+ ion-based clinical agent. Herein, we report that gadonanotubes are also ultrasensitive pH-smart probes with their r(1)/pH response from pH 7.0-7.4 being an order of magnitude greater than for any other MR contrast agent. This result suggests that gadonanotubes might be excellent candidates for the development of clinical agents for the early detection of cancer where the extracellular pH of tumors can drop to pH = 7 or below. In the present study, gadonanotubes have also been shown to maintain their integrity when challenged ex vivo by phosphate-buffered saline solution, serum, heat, and pH cycling.

机译：gadonanotubes的纳米级超顺磁性Gd3 +离子簇（11 x 5 nm）被限制在超短（20-80 nm）单壁碳纳米管胶囊中，是用于磁共振成像（MRI）的高性能T-1加权造影剂。。在1.5 T，37摄氏度和pH 6.5的情况下，gadonanotubes的r（1）弛豫性（每个Gd3 +离子约180 mM（-1）s（-1））比任何当前基于Gd3 +离子的临床方法大40倍代理商。在这里，我们报道gadonanotubes也是超灵敏的pH值智能探针，它们从pH 7.0-7.4的r（1）/ pH响应比任何其他MR造影剂大一个数量级。该结果表明，gadonanotubes可能是开发用于早期检测癌症的临床药物的极佳候选药物，其中肿瘤的细胞外pH可以降至pH = 7或更低。在本研究中，gadonanotubes还显示出在磷酸盐缓冲盐溶液，血清，热和pH循环中进行离体攻击时可以保持其完整性。

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《Nano letters》 |2008年第2期|共5页
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Hartman KB; Laus S; Bolskar RD; Muthupillai R; Helm L; Toth E; Merbach AE; Wilson LJ;
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正文语种 eng
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MRI CONTRAST AGENTS; INTRACELLULAR PH; EXTRACELLULAR PH; AQUEOUS-SOLUTION; IN-VIVO; RELAXIVITY; TUMORS; GD-AT-C-60(OH)(X); NANOPARTICLES; LYMPHOCYTES;

机译：MRI造影剂;细胞内PH;细胞外PH;水溶液;体内;相关性;肿瘤;GD-AT-C-60（OH）（X）;纳米颗粒;淋巴细胞;

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1. Gadonanotubes as ultrasensitive pH-smart probes for magnetic resonance imaging [J] . Hartman KB, Laus S, Bolskar RD, Nano letters . 2008,第2期

机译：Gadonanotubes作为用于磁共振成像的超灵敏pH值智能探针
2. Gadofullerenes and Gadonanotubes: A New Paradigm for High-Performance Magnetic Resonance Imaging Contrast Agent Probes [J] . Sitharaman Balaji, Wilson Lon J Journal of biomedical nanotechnology . 2007,第4期

机译：Gadofullerenes和Gadonanotubes：高性能磁共振成像造影剂探针的新范例
3. Gadofullerenes and Gadonanotubes: A New Paradigm for High-Performance Magnetic Resonance Imaging Contrast Agent Probes [J] . Sitharaman Balaji, Wilson Lon J Journal of biomedical nanotechnology . 2007,第4期

机译：Gadofullerenes和Gadonanotubes：高性能磁共振成像造影剂探针的新范例
4. Ultrasensitive Si nanowire probe for magnetic resonance detection [C] . Seo Yong-Jun, Toda Masaya, Kawai Yusuke, IEEE International Conference on Micro Electro Mechanical Systems . 2014

机译：用于磁共振检测的超灵敏硅纳米线探针
5. Signal processing techniques for improving image reconstruction of parallel Magnetic Resonance Imaging and dynamic Magnetic Resonance Imaging [D] . She, Huajun 2015

机译：用于改善并行磁共振成像和动态磁共振成像的图像重建的信号处理技术
6. Ultrasensitive magnetic resonance imaging of systemic reactive oxygen species in vivo for early diagnosis of sepsis using activatable nanoprobes [O] . Huan Wang, Dongqin Yu, Bo Li, 2019

机译：体内全身活性氧的超灵敏磁共振成像可使用可激活的纳米探针对败血症进行早期诊断
7. MODERATED EPOSTERS1385Longitudinal strain assessment in dilated cardiomyopathy patients using a novel accelerated DENSE sequence1407Simultaneous T1 and T2 cardiac quantification with CABIRIA: initial clinical experience1423Head-to-head comparison of acceleration algorithms in 4-dimensional flow CMR1502Left ventricular function and size evaluated by hybrid cardiac positron emission tomography-magnetic resonance: Intraindividual comparison of left ventricular ejection fraction and ventricular volumes derived by two modalities1510Left Atrium assessed by Cardiovascular Magnetic Resonance at 1.5 and 3 Tesla – age and gender effects1514Comparison of Free Breathing Cardiac MRI Radial technique to the Standard Multi breath-hold cine SSFP CMR technique for the assessment of LV Volumes and Function1536Self-navigated free-breathing isotropic 3D whole heart phase sensitive inversion recovery magnetic resonance without navigator for detection of myocardial infarction1547Assessment of Right Ventricular Strain Using Myocardial Deformation Recovery Semi Automated Technique: Initial Experience and Normal Values1586Tissue tracking myocardial deformation analysis and prediction of left ventricular remodeling in acute myocardial infarction1589Investigating strategies for optimal 31P MRS clinical cardiac at 3T: Initial Results1620Quantitative Criteria for the Diagnosis of the Congenital Absence of Pericardium by Cardiac Magnetic Resonance1632Widespread tissue injury during acute myocardial infarction: evidence from advanced CMR relaxometry1322Computed tomography coronary angiography verSus sTRess cArdiac magneTic rEsonance for the manaGement of sYmptomatic revascularized patients: a cost effectiveness study (STRATEGY study)1339Comparison of low- versus high-dose of gadobutrol for late gadolinium enhancement imaging at 1.5 Tesla: a clinical feasibility study1347Multi-parametric Cardiac Magnetic Resonance for Prediction of Cardiac Complications in Thalassemia Intermedia: a Prospective Multicenter Study1461Prognostic value of Cardiovascular Magnetic Resonance derived indexes of myocardial fibrosis in heart transplant recipients1523The role of CMR in the acute phase of hospitalization: changing paradigms1542Preoperative CMR-based score predict ventricular response after surgical left ventricular reconstruction in ischemic heart failure patients1555Excellent response rate to cardiac resynchronization therapy guided with magnetic resonance imaging1626The ECG as a predictor of arrhythmogenic substrate on Cardiac Magnetic Resonance Imaging in patients undergoing ablation for premature ventricular contractions1649Comparison of T1-mapping at 3.0T CMR and angiographic APPROACH score for area at risk assessment in ST-segment elevation myocardial infarction1340Pathological correlates of left bundle branch disease in patients with non-ischemic cardiomyopathy: a cardiovascular magnetic resonance study1342Myocardial remodelling and fibrosis in nonischaemic dilated cardiomyopathy: insights from cardiovascular magnetic resonance1411The association between fibrosis and contractile dysfunction in hypertrophic cardiomyopathy assessed by cardiovascular magnetic resonance1622Persistent myocardial inflammation due to intramyocardial haemorrhage in reperfused STEMI as a precursor to adverse LV remodelling - insights from multi-parametric mapping1566Semiquantitative analysis of low and high b value DWI for detecting myocardial edema in acute myocarditis1567Value of Cardiac MRI In Detecting Coronary Artery Disease In Newly Diagnosed Systolic Dysfunction1570Usefulness of cardiac magnetic resonance in tuberous sclerosis complex1578Papillary muscles offer further insight into hypertrophied hearts: a cardiovascular magnetic resonance study1627Diagnostic and clinical implications of CMR timing (early versus late) in patients with troponin positive acute coronary syndromes and unobstructed coronary arteries: Table 1. [O] . Upasana Tayal, Alexandros Kallifatidis, P. Garg, 2016

机译：在使用新的扩张型心肌病的患者缓和EPOSTERS1385Longitudinal应变评估加速DENSE sequence1407Simultaneous T1和T2与CABIRIA心脏定量：在4维流动的加速算法初始临床experience1423Head对头比较CMR1502Left心室功能和尺寸由混合心脏正电子发射断层摄影术评价 - 磁性共振：由两个modalities1510Left庭派生左室射血分数和心室体积的个体间的比较，在1.5和3特斯拉评估心血管磁共振 - 免费的年龄和性别effects1514Comparison呼吸心脏MRI径向技术标准的多屏气电影SSFP CMR技术的LV卷和Function1536Self-导航自由呼吸各向同性3D整个心脏相位敏感反转恢复磁共振导航仪没有检测右Ventricu心肌infarction1547Assessment的评估拉尔菌株使用心肌变形恢复半自动技术：初步经验和正常Values1586Tissue跟踪心肌变形分析和预测左室重构急性心肌infarction1589Investigating策略优化31P MRS临床心脏在3T：初始Results1620Quantitative标准的先天缺失的诊断心包心脏磁Resonance1632Widespread组织损伤急性心肌梗死时：证据先进CMR relaxometry1322Computed CT冠状动脉成像与压力心脏磁共振对症的管理吻合血管患者：成本效益研究（战略研究）1339Comparison低与高剂量钆布醇在1.5特斯拉晚钆增强成像的临床可行性，在中间型地贫心脏并发症的预测study1347Multi参数心脏核磁共振的前瞻性德穆尔心血管磁共振的ticenter Study1461Prognostic价值衍生心肌纤维化指标在住院的急性期CMR的心脏移植recipients1523The作用：改变基于CMR-paradigms1542Preoperative比分预测缺血性心脏衰竭patients1555Excellent响应速度外科左心室重建心脏再同步化后心室反应治疗与磁共振imaging1626The ECG导引作为心脏磁共振成像致心律失常性基板的在ST段抬高心肌infarction1340Pathological在风险评估经历在3.0T CMR T1映射的室性早搏contractions1649Comparison和血管造影APPROACH分数区域消融患者的预测左束支传导疾病的患者与非缺血性心肌病相关因素：心血管磁共振study1342Myocardial重塑和纤维化nonischaemic扩张型心肌病：在从在由心血管磁性resonance1622Persistent心肌炎症评估肥厚型心肌病的纤维化和收缩功能障碍之间心血管磁性resonance1411The协会由于心肌内出血景点在再灌注STEMI为先导，以不利的LV重塑 - 从低的多参数mapping1566Semiquantitative分析和高的b值DWI的见解为在心脏MRI检测冠状动脉疾病急性myocarditis1567Value在结节性硬化症complex1578Papillary肌肉初诊收缩期Dysfunction1570Usefulness心脏磁共振检测心肌水肿提供进一步的深入了解肥大心脏：心血管磁共振study1627Diagnostic和CMR定时的临床意义（早期与晚）患者肌钙蛋白阳性的急性冠脉综合征和通畅的冠状动脉：表1。

Gadonanotubes as ultrasensitive pH-smart probes for magnetic resonance imaging

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