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Biofunctionalized magnetic hydrogel nanospheres of magnetite and k-carrageenan

机译：磁铁矿和角叉菜胶的生物功能化磁性水凝胶纳米球

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Magnetic hydrogel k-carrageenan nanospheres were successfully prepared via water-in-oil (w/o) microemulsions combined with thermally induced gelation of the polysaccharide. The size of the nanospheres (an average diameter (0) of about 50 and 75 nm) was modulated by varying the concentration of surfactant. The nanospheres contained superparamagnetic magnetite nanoparticles (08 nm), previously prepared by co-precipitation within the biopolymer. Carboxyl groups, at a concentration of about 4 mmol g-1, were successfully grafted at the surface of these magnetic nanospheres via carboxymethylation of the K-carrageenan. The carboxylated nanospheres were shown to be thermo-sensitive in the 37-45 °C temperature range, indicating their potential as thermally controlled delivery systems for drugs and/or magnetic particles at physiological temperatures. Finally, preliminary results have been obtained for IgG antibody conjugation of the carboxylated nanospheres and the potential of these systems for bio-applications is discussed.Supplementary data are available from stacks.iop.org/Nano/20/355602
机译：磁性水凝胶k-角叉菜胶纳米球是通过油包水（w / o）微乳与多糖的热诱导胶凝作用成功制备的。通过改变表面活性剂的浓度来调节纳米球的尺寸（平均直径（0）约为50和75nm）。纳米球包含超顺磁性磁铁矿纳米粒子（08纳米），先前是通过在生物聚合物中共沉淀制备的。通过K-角叉菜胶的羧甲基化，将浓度约4 mmol g-1的羧基成功接枝到了这些磁性纳米球的表面。羧基化的纳米球在37-45°C的温度范围内表现出热敏性，表明它们在生理温度下作为药物和/或磁性颗粒的热控制传递系统的潜力。最后，已获得有关羧基化纳米球IgG抗体缀合的初步结果，并讨论了这些系统在生物应用中的潜力。补充数据可从stacks.iop.org/Nano/20/355602获得

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