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Capillarity-induced disassembly of virions in carbon nanotubes

机译:毛细作用引起的碳纳米管中病毒体的分解

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Studying the transport and fate of viruses through nanochannels is of great importance. By using the nanochannel of a carbon nanotube ( CNT) as an ideal model, we evaluated the possibility of capillarity-induced viral transport through a closely fitting nanochannel and explored the mechanisms involved. It is shown both experimentally and theoretically that Cowpea mosaic virus can enter CNTs by capillarity. However, when introduced into a nanotube the protein capsid may disassemble. During the initial capillary filling stage, anomalous needle-shaped high pressure exists in the centre of the nanotube's entrance. This high pressure, combining with the significant negative pressure within the nanotube, may account for the disassembly of the virions.
机译:研究病毒通过纳米通道的运输和命运非常重要。通过使用碳纳米管(CNT)的纳米通道作为理想模型,我们评估了毛细管现象通过紧密配合的纳米通道引起的病毒运输的可能性,并探讨了涉及的机制。从实验和理论上都证明Cow豆花叶病毒可以通过毛细作用进入碳纳米管。但是,当引入纳米管时,蛋白质衣壳可能会分解。在最初的毛细管填充阶段,纳米管入口的中心存在异常的针状高压。这种高压与纳米管内显着的负压相结合,可以解释病毒体的分解。

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