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Synthesis and characterization of PVP-coated large core iron oxide nanoparticles as an MRI contrast agent

机译：核磁共振造影剂PVP包覆的大芯氧化铁纳米粒子的合成与表征

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摘要

The purpose of this study was to synthesize biocompatible polyvinylpyrrolidone ( PVP)-coated iron oxide ( PVP-IO) nanoparticles and to evaluate their efficacy as a magnetic resonance imaging ( MRI) contrast agent. The PVP-IO nanoparticles were synthesized by a thermal decomposition method and characterized by x-ray diffraction ( XRD), transmission electron microscopy ( TEM), dynamic light scattering ( DLS), and a superconducting quantum interface device ( SQUID). The core size of the particles is about 8-10 nm and the overall size is around 20-30 nm. The measured r(2) ( reciprocal of T-2 relaxation time) and r(2)* ( reciprocal of T-2* relaxation time) are 141.2 and 338.1 ( s mM)(-1), respectively. The particles are highly soluble and stable in various buffers and in serum. The macrophage uptake of PVP-IO is comparable to that of Feridex as measured by a Prussian blue iron stain and phantom study. The signal intensity of a rabbit liver was effectively reduced after intravenous administration of PVP-IO. Therefore PVP-IO nanoparticles are potentially useful for T-2-weighted MR imaging.
机译：这项研究的目的是合成生物相容性聚乙烯吡咯烷酮（PVP）包覆的氧化铁（PVP-10）纳米粒子，并评估其作为磁共振成像（MRI）造影剂的功效。通过热分解方法合成了PVP-10纳米颗粒，并通过X射线衍射（XRD），透射电子显微镜（TEM），动态光散射（DLS）和超导量子界面装置（SQUID）对其进行了表征。粒子的核心尺寸约为8-10 nm，整体尺寸约为20-30 nm。测得的r（2）（T-2弛豫时间的倒数）和r（2）*（T-2 *弛豫时间的倒数）分别为141.2和338.1（s mM）（-1）。该颗粒在各种缓冲液和血清中高度可溶且稳定。通过普鲁士蓝铁染色和体模研究测量，PVP-10的巨噬细胞摄取与Feridex相当。静脉内施用PVP-10后，兔子肝脏的信号强度被有效降低。因此，PVP-10纳米颗粒可潜在地用于T-2加权MR成像。

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