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Magnetic molecularly imprinted polymer for aspirin recognition and controlled release

机译：磁性分子印迹聚合物可识别和控制释放阿司匹林

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摘要

Core—shell structural magnetic molecularly imprinted polymers (magnetic MIPs) with combined properties of molecular recognition and controlled release were prepared and characterized. Magnetic MIPs were synthesized by the co-polymerization of methacrylic acid (MAA) and trimethylolpropane trimethacrylate (TRIM) around aspirin (ASP) at the surface of double-bond-functionalized Fe_3O_4 nanoparticles in chloroform. The obtained spherical magnetic MIPs with diameters of about 500 nm had obvious superparamagnetism and could be separated quickly by an external magnetic field. Binding experiments were carried out to evaluate the properties of magnetic MIPs and magnetic non-molecularly imprinted polymers (magnetic NIPs). The results demonstrated that the magnetic MIPs had high adsorption capacity and selectivity to ASP. Moreover, release profiles and release rate of ASP from the ASP-loaded magnetic MIPs indicated that the magnetic MIPs also had potential applications in drug controlled release.
机译：制备并表征了具有分子识别和控释特性的核-壳结构磁性分子印迹聚合物（磁性MIP）。通过在氯仿中双键功能化的Fe_3O_4纳米粒子表面，在阿司匹林（ASP）周围，甲基丙烯酸（MAA）和三羟甲基丙烷三甲基丙烯酸酯（TRIM）的共聚反应合成磁性MIP。所获得的直径约500 nm的球形磁性MIP具有明显的超顺磁性，并且可以被外部磁场快速分离。进行结合实验以评估磁性MIP和磁性非分子印迹聚合物（磁性NIP）的性能。结果表明，磁性MIP具有较高的吸附能力和对ASP的选择性。此外，ASP加载的磁性MIP的ASP释放曲线和释放速率表明，磁性MIP在药物控制释放中也具有潜在的应用。

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