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Hydrophilic modification of neural microelectrode arrays based on multi-walled carbon nanotubes

机译:基于多壁碳纳米管的神经微电极阵列的亲水改性

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To decrease the impedance of microelectrode arrays, for neuroscience applications we have fabricated and tested MEA based on multi-walled carbon nanotubes. With decreasing physical size of a microelectrode, its impedance increases and charge-transfer capability decreases. To decrease the impedance, the effective surface area of the electrode must generally be increased. We explored the effect of plasma treatment on the surface wettability of MWCNT. With a steam-plasma treatment the surface of MWCNT becomes converted from superhydrophobic to superhydrophilic; this hydrophilic property is attributed to-OH bonding on the surface of MWCNT. We reported the synthesis at 400 °C of MWCNT on nickel-titanium multilayered metal catalysts by thermal chemical vapor deposition. Applying plasma with a power less than 25 W for 10 s improved the electrochemical and biological properties, and circumvented the limitation of the surface reverting to a hydrophobic condition; a hydrophilic state is maintained for at least one month. The MEA was used to record neural signals of a lateral giant cell from an American crayfish. The response amplitude of the action potential was about 275 μV with 1 ms period; the recorded data had a ratio of signal to noise up to 40.12 dB. The improved performance of the electrode makes feasible the separation of neural signals and the recognition of their distinct shapes. With further development the rapid treatment will be useful for long-term recording applications.
机译:为了降低微电极阵列的阻抗,对于神经科学应用,我们已经制造并测试了基于多壁碳纳米管的MEA。随着微电极的物理尺寸减小,其阻抗增加并且电荷转移能力降低。为了降低阻抗,通常必须增加电极的有效表面积。我们探索了等离子体处理对MWCNT表面润湿性的影响。通过蒸汽等离子体处理,MWCNT的表面从超疏水性转变为超亲水性。该亲水性归因于MWCNT表面上的-OH键。我们报道了通过热化学气相沉积在镍钛多层金属催化剂上于400℃下合成MWCNT。施加功率小于25 W的等离子体10 s改善了电化学和生物学性能,并规避了表面恢复疏水性的限制。亲水状态保持至少一个月。 MEA用于记录来自美国小龙虾的外侧巨细胞的神经信号。动作电位的响应幅度大约为275μV,周期为1 ms;记录的数据具有高达40.12 dB的信噪比。电极性能的提高使得分离神经信号和识别其不同形状成为可能。随着进一步的发展,快速治疗将对长期记录应用有用。

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