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Degradability of superparamagnetic nanoparticles in a model of intracellular environment: Follow-up of magnetic, structural and chemical properties

机译：细胞内环境模型中超顺磁性纳米粒子的可降解性：磁，结构和化学性质的跟踪

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The unique magnetic properties of iron oxide nanoparticles have paved the way for various biomedical applications, such as magnetic resonance cellular imaging or magnetically induced therapeutic hyperthermia. Living cells interact with nanoparticles by internalizing them within intracellular acidic compartments. Although no acute toxicity of iron oxide nanoparticles has been reported up to now, the mechanisms of nanoparticle degradation by the cellular environment are still unknown. In the organism, the long term integrity and physical state of iron-based nanoparticles are challenged by iron homeostasis. In this study, we monitored the degradation of 7 nm sized maghemite nanoparticles in a medium mimicking the intracellular environment. Magnetic nanoparticles with three distinct surface coatings, currently evaluated as MRI contrast agents, were shown to exhibit different kinetics of dissolution at an acidic pH in the presence of a citrate chelating agent. Our assessment of the physical state of the nanoparticles during degradation revealed that the magnetic properties, size distribution and structure of the remaining nanocrystals were identical to those of the initial suspension. This result suggests a model for nanoparticle degradation with rapidly dissolved nanocrystals and a reservoir of intact nanoparticles.
机译：氧化铁纳米粒子的独特磁性已经为各种生物医学应用铺平了道路，例如磁共振细胞成像或磁感应治疗性高温。活细胞通过将其内化在细胞内酸性隔室内而与纳米颗粒相互作用。尽管迄今尚未报道氧化铁纳米颗粒的急性毒性，但细胞环境对纳米颗粒降解的机理仍然未知。在生物体中，铁稳态会挑战铁基纳米颗粒的长期完整性和物理状态。在这项研究中，我们监测了模拟细胞内环境的培养基中7 nm大小的磁赤铁矿纳米粒子的降解。具有三种不同表面涂层的磁性纳米颗粒（目前被评估为MRI造影剂）显示出在柠檬酸盐螯合剂存在下在酸性pH下具有不同的溶解动力学。我们对降解过程中纳米颗粒的物理状态的评估表明，剩余纳米晶体的磁性，尺寸分布和结构与初始悬浮液相同。该结果提出了具有快速溶解的纳米晶体和完整纳米颗粒储存库的纳米颗粒降解模型。

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