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Minute synthesis of extremely stable gold nanoparticles

机译:极稳定金纳米粒子的分钟合成

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摘要

We describe a rapid environmentally friendly wet-chemical approach to synthesize extremely stable non-toxic, biocompatible, water-soluble monodispersed gold nanoparticles (AuNPs) in one step at room temperature. The particles have been successfully achieved in just a few minutes by merely adding sodium hydroxide (NaOH) acting as an initiator for the reduction of HAuCl4 in aqueous solution in the presence of polyvinylpyrrolidone (PVP) without the use of any reducing agent. It is also proved to be highly efficient for the preparation of AuNPs with controllable sizes. The AuNPs show remarkable stability in water media with high concentrations of salt, various buffer solutions and physiological conditions in biotechnology and biomedicine. Moreover, the AuNPs are also non-toxic at high concentration (100 mu M). Therefore, it provides great opportunities to use these AuNPs for biotechnology and biomedicine. This new approach also involved several green chemistry concepts, such as the selection of environmentally benign reagents and solvents, without energy consumption, and less reaction time.
机译:我们描述了一种快速环保的湿化学方法,可在室温下一步合成极其稳定的无毒,生物相容性,水溶性单分散金纳米颗粒(AuNPs)。仅在聚乙烯吡咯烷酮(PVP)存在下,不使用任何还原剂的情况下,仅添加氢氧化钠(NaOH)作为引发剂即可还原水溶液中的HAuCl4,即可在短短几分钟内成功获得颗粒。它也被证明对于制备尺寸可控的AuNP非常有效。 AuNPs在高浓度盐,各种缓冲溶液和生物技术和生物医学中的生理条件下,在水介质中显示出显着的稳定性。此外,AuNP在高浓度(100μM)下也是无毒的。因此,它为将这些AuNP用于生物技术和生物医学提供了巨大的机会。这种新方法还涉及多个绿色化学概念,例如选择对环境无害的试剂和溶剂,而无需消耗能量,并且反应时间更短。

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