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The preparation of magnetically guided lipid based nanoemulsions using self-emulsifying technology

机译：利用自乳化技术制备磁导脂质纳米乳

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摘要

This paper reports an easy and highly reproducible preparation route, using self-emulsifying technology, for an orally administered high quality magnetically responsive drug delivery system. Hydrophobic iron oxide nanoparticles of about 5 nm in diameter were prepared and incorporated into the lipid core of the produced oil droplets of a self-nanoemulsifying drug delivery system (MagC(18)/SNEDDS). The produced nanoemulsion exhibits colloidal stability at high ionic strengths and temperatures. The observed value of the saturation magnetization at 2 K is approximate to 4.1 emu g(-1). The nanoemulsion displayed the magnetic properties of a non-interacting assembly of superparamagnetic particles and a low blocking temperature. Moreover the effect of MagC(18)/SNEDDS on biological systems in vitro was investigated in rodent fibroblasts (3T3 cells). The cytotoxicity studies show that none of the formulations tested affected cell activity significantly over the 24 h incubation. Such systems might have a potential use for oral delivery of poorly soluble compounds by extending the residence time of the formulation in the small intestine resulting in increased drug absorption values.
机译：本文报告了一种使用自我乳化技术的简便，可重复性高的制备途径，该途径可用于口服给药的高质量磁响应药物递送系统。制备了直径约为5 nm的疏水性氧化铁纳米颗粒，并将其掺入了自纳米乳化药物递送系统（MagC（18）/ SNEDDS）产生的油滴的脂质核中。产生的纳米乳液在高离子强度和温度下显示出胶体稳定性。 2 K时的饱和磁化强度的观测值约为4.1 emu g（-1）。该纳米乳液显示出超顺磁性颗粒的非相互作用组件的磁性能和低的封闭温度。此外，在啮齿动物成纤维细胞（3T3细胞）中研究了MagC（18）/ SNEDDS对体外生物系统的影响。细胞毒性研究表明，在24小时的孵育过程中，所测试的制剂均未显着影响细胞活性。通过延长制剂在小肠中的停留时间，导致药物吸收值增加，此类系统可能具有口服溶解性差的化合物的潜在用途。

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