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首页> 外文期刊>Nanotechnology >Biocompatible transferrin-conjugated sodium hexametaphosphate-stabilized gold nanoparticles: Synthesis, characterization, cytotoxicity and cellular uptake
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Biocompatible transferrin-conjugated sodium hexametaphosphate-stabilized gold nanoparticles: Synthesis, characterization, cytotoxicity and cellular uptake

机译：生物相容性转铁蛋白偶联的六偏磷酸钠稳定的金纳米粒子：合成，表征，细胞毒性和细胞摄取。

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摘要

The feasibility of using gold nanoparticles (AuNPs) for biomedical applications has led to considerable interest in the development of novel synthetic protocols and surface modification strategies for AuNPs to produce biocompatible molecular probes. This investigation is, to our knowledge, the first to elucidate the synthesis and characterization of sodium hexametaphosphate (HMP)-stabilized gold nanoparticles (Au-HMP) in an aqueous medium. The role of HMP, a food additive, as a polymeric stabilizing and protecting agent for AuNPs is elucidated. The surface modification of Au-HMP nanoparticles was carried out using polyethylene glycol and transferrin to produce molecular probes for possible clinical applications. Invitro cell viability studies performed using as-synthesized Au-HMP nanoparticles and their surface-modified counterparts reveal the biocompatibility of the nanoparticles. The transferrin-conjugated nanoparticles have significantly higher cellular uptake in J5 cells (liver cancer cells) than control cells (oral mucosa fibroblast cells), as determined by inductively coupled plasma mass spectrometry. This study demonstrates the possibility of using an inexpensive and non-toxic food additive, HMP, as a stabilizer in the large-scale generation of biocompatible and monodispersed AuNPs, which may have future diagnostic and therapeutic applications.
机译：在生物医学应用中使用金纳米颗粒（AuNPs）的可行性已引起人们对开发新型合成方案和AuNPs的表面修饰策略以生产生物相容性分子探针的兴趣。就我们所知，这项研究是第一个阐明在水介质中六偏磷酸钠（HMP）稳定的金纳米颗粒（Au-HMP）的合成和表征。阐明了食品添加剂HMP作为AuNPs的聚合物稳定和保护剂的作用。使用聚乙二醇和转铁蛋白对Au-HMP纳米颗粒进行表面修饰，以生产可能用于临床的分子探针。使用合成的Au-HMP纳米粒子及其表面改性的对应物进行的体外细胞活力研究揭示了纳米粒子的生物相容性。通过电感耦合等离子体质谱法测定，与运铁蛋白偶联的纳米颗粒在J5细胞（肝癌细胞）中的细胞摄取明显高于对照细胞（口腔粘膜成纤维细胞）。这项研究表明，在大规模生产生物相容性和单分散的AuNPs时，有可能使用便宜且无毒的食品添加剂HMP作为稳定剂，这可能在未来的诊断和治疗应用中。

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