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首页> 外文期刊>Nature cell biology >Cofilin/ADF is required for cell motility during Drosophila ovary development and oogenesis.
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Cofilin/ADF is required for cell motility during Drosophila ovary development and oogenesis.

机译：果蝇卵巢发育和卵子形成过程中细胞运动需要Cofilin / ADF。

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The driving force behind cell motility is the actin cytoskeleton. Filopodia and lamellipodia are formed by the polymerization and extension of actin filaments towards the cell membrane. This polymerization at the barbed end of the filament is balanced by depolymerization at the pointed end, recycling the actin in a 'treadmilling' process. One protein involved in this process is cofilin/actin-depolymerizing factor (ADF), which can depolymerize actin filaments, allowing treadmilling to occur at an accelerated rate. Cofilin/ADF is an actin-binding protein that is required for actin-filament disassembly, cytokinesis and the organization of muscle actin filaments. There is also evidence that cofilin/ADF enhances cell motility, although a direct requirement in vivo has not yet been shown. Here we show that Drosophila cofilin/ADF, which is encoded by the twinstar (tsr) gene, promotes cell movements during ovary development and oogenesis. During larval development, cofilin/ADF is required for the cell rearrangement needed for formation of terminal filaments, stacks of somatic cells that are important for the initiation of ovarioles. It is also required for the migration of border cells during oogenesis. These results show that cofilin/ADF is an important regulator of actin-based cell motility during Drosophila development.
机译：细胞运动背后的驱动力是肌动蛋白细胞骨架。丝状伪足和片状脂质伪足是通过肌动蛋白丝向细胞膜的聚合和延伸而形成的。长丝带刺末端的聚合反应通过尖端的解聚反应达到平衡，从而使肌动蛋白在“跑步研磨”过程中循环利用。此过程涉及的一种蛋白质是cofilin /肌动蛋白解聚因子（ADF），可以使肌动蛋白丝解聚，从而加快跑步速度。 Cofilin / ADF是肌动蛋白结合蛋白，是肌动蛋白丝分解，胞质分裂和肌肉肌动蛋白丝组织所必需的。还有证据表明cofilin / ADF可增强细胞运动性，尽管尚未显示出体内直接需求。在这里，我们显示了由双星（tsr）基因编码的果蝇cofilin / ADF在卵巢发育和卵子形成过程中促进细胞运动。在幼体发育过程中，需要cofilin / ADF来进行细胞重排，以形成末端细丝，这些细小体细胞的堆叠对于卵巢的形成很重要。在卵子发生过程中边界细胞的迁移也需要它。这些结果表明，cofilin / ADF是果蝇发育过程中基于肌动蛋白的细胞运动的重要调节剂。

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