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首页> 外文期刊>Nature reviews Immunology >γ δ T cell effector functions: A blend of innate programming and acquired plasticity
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γ δ T cell effector functions: A blend of innate programming and acquired plasticity

机译：γδT细胞效应子功能：先天编程与后天可塑性的融合

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摘要

γ δ T cells have several innate cell-like features that allow their early activation following recognition of conserved stress-induced ligands. Here we review recent observations revealing the ability of γ δ T cells to rapidly produce cytokines that regulate pathogen clearance, inflammation and tissue homeostasis in response to tissue stress. These studies provide insights into how they acquire these properties, through both developmental programming in the thymus and functional polarization in the periphery. Innate features of γ δ T cells underlie their non-redundant role in several physiopathological contexts and are therefore being exploited in the design of new immunotherapeutic approaches.
机译：γδT细胞具有多种先天性细胞样特征，可在识别保守的应激诱导的配体后使其早期活化。在这里，我们回顾了最近的发现，这些发现揭示了γδT细胞快速产生细胞因子来调节病原体清除，炎症和组织稳态以响应组织压力的能力。这些研究通过胸腺的发育程序设计和外周的功能极化，提供了有关如何获得这些特性的见解。 γδT细胞的先天特征是它们在几种生理病理学背景下的非冗余作用的基础，因此正被用于新的免疫治疗方法的设计中。

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