Exploring genetic interactions and networks with yeast

Boone C; Bussey H; Andrews BJ

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Exploring genetic interactions and networks with yeast

机译：探索与酵母的遗传相互作用和网络

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The development and application of genetic tools and resources has enabled a partial genetic-interaction network for the yeast Saccharomyces cerevisiae to be compiled. Analysis of the network, which is ongoing, has already provided a clear picture of the nature and scale of the genetic interactions that robustly sustain biological systems, and how cellular buffering is achieved at the molecular level. Recent studies in yeast have begun to define general principles of genetic networks, and also pave the way for similar studies in metazoan model systems. A comparative understanding of genetic-interaction networks promises insights into some long-standing genetic problems, such as the nature of quantitative traits and the basis of complex inherited disease.

机译：遗传工具和资源的开发和应用已使用于酿酒酵母的部分遗传相互作用网络得以编译。正在进行的网络分析已经清楚地显示了牢固维持生物系统的遗传相互作用的性质和规模，以及如何在分子水平上实现细胞缓冲。酵母的最新研究已开始定义遗传网络的一般原理，也为后生动物模型系统中的类似研究铺平了道路。对遗传相互作用网络的比较理解有望深入了解一些长期存在的遗传问题，例如数量性状的性质和复杂遗传疾病的基础。

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《Nature reviews. Genetics》 |2007年第6期|共13页
作者
Boone C; Bussey H; Andrews BJ;
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正文语种 eng
中图分类遗传学;
关键词
SACCHAROMYCES-CEREVISIAE GENOME; SYNTHETIC DOSAGE LETHALITY; FUNCTIONAL GENOMICS; MULTICOMPONENT THERAPEUTICS; DROSOPHILA-MELANOGASTER; SIGNALING PATHWAYS; SECRETORY PATHWAY; PROTEIN COMPLEXES; SMALL MOLECULES; IDENTIFY GENES;

机译：糖酵母-酿酒酵母基因组;合成剂量联用性;功能基因组学;多组分治疗;果蝇-黑皮瘤;信号通路;保密通路;蛋白质复合物;小分子;鉴定基因;

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2. Exploring genetic interactions and networks with yeast [J] . Boone C, Bussey H, Andrews BJ Nature reviews. Genetics . 2007,第6期

机译：探索与酵母的遗传相互作用和网络
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5. Exploring Centrality-Lethality Rule from Evolution Constraint on Essential Hub and Nonessential Hub in Yeast Protein-Protein Interaction Network [C] . Yun-yuan, Dong, Jun, Yang, Qi-jun, Liu, Computational Intelligence and Security (CIS), 2011 Seventh International Conference on . 2011

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6. Computational methods to explore chemical and genetic interaction networks for novel human therapies. [D] . Deshpande, Raamesh. 2013

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8. Finding friends and enemies in an enemies-only network: A graph diffusion kernel for predicting novel genetic interactions and co-complex membership from yeast genetic interactions [O] . Qi, Yan, Suhail, Yasir, Lin, Yu-yi, 2008

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Exploring genetic interactions and networks with yeast

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