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首页> 外文期刊>Nature reviews. Genetics >Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cells
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Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cells

机译:果蝇干细胞的纺锤定向,不对称分裂和肿瘤抑制

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摘要

Recent genetic studies in flies have added further support to an increasing body of evidence that suggests that stem cells might be the cell-of-origin of certain tumours. Malfunction of the mechanisms that control the division of stem cells and the developmental fate of the two resulting daughters could be one of the initial events that steers cells into malignant transformation. These studies suggest a role for controlled spindle orientation in suppressing stem-cell overgrowth. In parallel, the machinery that drives asymmetry in stem cells has been further characterized, identifying new components and uncovering the unique, highly sophisticated behaviour of centrosomes in these cells.
机译:近期关于果蝇的遗传研究为越来越多的证据表明,干细胞可能是某些肿瘤的起源细胞提供了更多的支持。控制干细胞分裂的机制失灵以及由此产生的两个子代的发育命运可能是引导细胞发生恶性转化的最初事件之一。这些研究表明受控纺锤体定向在抑制干细胞过度生长中的作用。同时,驱动干细胞不对称性的机制已得到进一步表征,可以识别新成分并揭示这些细胞中中心体独特,高度复杂的行为。

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