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首页> 外文期刊>Natural product communications >A comparative study of the antioxidant/prooxidant effects of carvacrol and thymol at various concentrations on membrane and DNA of parental and drug resistant H1299 cells
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A comparative study of the antioxidant/prooxidant effects of carvacrol and thymol at various concentrations on membrane and DNA of parental and drug resistant H1299 cells

机译：香芹酚和百里香酚不同浓度对亲代和耐药H1299细胞膜和DNA的抗氧化/促氧化作用的比较研究

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摘要

Carvacrol and thymol, both used as flavor agents in cosmetic and food products, have prooxidant and antioxidant activities. To clarify the mechanisms of their cytotoxicity and the factors affecting their antioxidant/prooxidant activities, we investigated cell membrane and DNA damage induced by carvacrol and thymol in parental and drug-resistant human lung cancer cell lines. After 24 and 48 hour incubation periods, the cytotoxicity of carvacrol (IC_(50) 380 and 244 μM) was found to be higher than that of thymol (IC_(50) 497 and 266 μM) in parental cells. However, thymol showed higher cytotoxic effects in drug resistant H1299 cells for three incubation periods. Also, carvacrol and thymol, at higher concentrations, increased malondealdehyde (MDA) levels causing membrane damage and 8-hydroxy deoxyguanozine (8-OHdG) levels, causing DNA damage to both parental and drug resistant cells. On the other hand, carvacrol and thymol protected the cells against H_2O_2-induced cytotoxicity, and membrane and DNA damage when the cells were preincubated with these two compounds at lower concentration (
机译：香芹酚和百里酚都用作化妆品和食品中的调味剂，具有抗氧化剂和抗氧化剂的活性。为了阐明它们的细胞毒性机制以及影响其抗氧化剂/抗氧化剂活性的因素，我们研究了香芹酚和百里酚在亲代和耐药性人肺癌细胞系中诱导的细胞膜和DNA损伤。孵育24和48小时后，发现香芹酚（IC_（50）380和244μM）在亲代细胞中的细胞毒性高于百里酚（IC_（50）497和266μM）。然而，百里酚在三个潜伏期对耐药的H1299细胞显示出更高的细胞毒性作用。同样，更高浓度的香芹酚和百里香酚会增加丙二醛（MDA）含量，从而导致膜损伤和8-羟基脱氧鸟嘌呤（8-OHdG）含量，从而对亲代和耐药细胞造成DNA损伤。另一方面，香芹酚和百里香酚可保护细胞免受H_2O_2诱导的细胞毒性以及细胞在H_2O_2孵育前与较低浓度（

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