Ventral medial prefrontal cortex neuronal ensembles mediate context-induced relapse to heroin.

Bossert JM; Stern AL; Theberge FR; Cifani C; Koya E; Hope BT; Shaham Y

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Ventral medial prefrontal cortex neuronal ensembles mediate context-induced relapse to heroin.

机译：腹内侧前额叶皮层神经元集成介导上下文诱导的海洛因复发。

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In a rat model of context-induced relapse to heroin, we identified sparsely distributed ventral medial prefrontal cortex (mPFC) neurons that were activated by the heroin-associated context. Selective pharmacogenetic inactivation of these neurons inhibited context-induced drug relapse. A small subset of ventral mPFC neurons formed neuronal ensembles that encode the learned associations between heroin reward and heroin-associated contexts; re-activation of these neuronal ensembles by drug-associated contexts during abstinence provoked drug relapse.

机译：在情境引起的海洛因复发的大鼠模型中，我们确定了稀疏分布的腹侧内侧前额叶皮层（mPFC）神经元，该神经元被海洛因相关的情境激活。这些神经元的选择性药物遗传学失活抑制了情境诱导的药物复发。腹侧mPFC神经元的一小部分形成神经元集合，编码海洛因奖赏与海洛因相关情境之间的学习关联。禁欲期间与药物相关的环境重新激活这些神经元集成体会导致药物复发。

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《Nature neuroscience》 |2011年第4期|共3页
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Bossert JM; Stern AL; Theberge FR; Cifani C; Koya E; Hope BT; Shaham Y;
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1. Ventral medial prefrontal cortex neuronal ensembles mediate context-induced relapse to heroin. [J] . Bossert JM, Stern AL, Theberge FR, Nature neuroscience . 2011,第4期

机译：腹内侧前额叶皮层神经元集成介导上下文诱导的海洛因复发。
2. The effect of chemogenetic inhibition of an alcohol-context encoding neuronal ensemble in the ventral subiculum on context-induced relapse, after punishment imposed abstinence in rats [J] . Jennifer Van Klaveren, Nathan Marchant, Dustin Schetters, IBRO Reports . 2019,第4期

机译：禁欲大鼠禁食后化学上抑制腹侧支气管内酒精上下文编码神经元集合对情境诱发的复发的影响
3. The Emergence of a Stable Neuronal Ensemble from a Wider Pool of Activated Neurons in the Dorsal Medial Prefrontal Cortex during Appetitive Learning in Mice [J] . Brebner Leonie S., Ziminski Joseph J., Margetts-Smith Gabriella, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2020,第2期

机译：在小鼠的快速学习期间，在背侧前额叶皮层中较宽的活化神经元的稳定神经元聚组的出现
4. Prefrontal cortex deletion affects the dopaminergic neural firing complexity in nicotine-treated ventral tegmental area [C] . Chen Ting Y., Dragomir Andrei, Zhang Die, 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2010

机译：前额叶皮层缺失影响尼古丁治疗的腹侧被盖区多巴胺能神经放电的复杂性
5. Memory representation in the medial prefrontal cortex Cortical communication, and the development of a prefrontal ensemble code for associative memory. [D] . Morrissey, Mark. 2016

机译：内侧前额叶皮层皮质通讯中的记忆表示，以及用于关联记忆的前额综码的发展。
6. Ventral medial prefrontal cortex neuronal ensembles mediate context-induced relapse to heroin [O] . Jennifer M. Bossert, Anna L. Stern, Florence R.M. Theberge, -1

机译：腹侧前列前额叶皮质神经元合奏介导对海洛因的背景诱发的复发
7. Ventral medial prefrontal cortex neuronal ensembles mediate context-induced relapse to heroin [O] . Bossert JM, Stern AL, Theberge FR, 2011

机译：腹内侧前额叶皮层神经元集成介导背景诱导的海洛因复发

Ventral medial prefrontal cortex neuronal ensembles mediate context-induced relapse to heroin.

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